取代吲哚-3-甲腈類化合物的合成.pdf

1、東南大學(xué)碩士學(xué)位論文取代吲哚3甲腈類化合物的合成姓名：楊燕美申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：葛裕華20080401東南大學(xué)碩1：論文AbstractAonepotsynthesisofsubstitutedindole3carbonitrilewascardedoutusingsubstitutedindole3—carboxaldehydeandhydroxylaminehydrochlorideunderacidiccon

2、ditionInthepapertherearetwentyfourcompoundsofsubstitutedindole一3calbonitriletobesynthesizedTheyarelistedasfollowing：(1)4methoxyindole3一carbonitrile木，5methoxyindole一3一carbonitrile，7methoxyindole一3一carbonitrile木；(2)4benzyl

3、oxyindole一3一carbonitrile宰，5benzyloxyindole一3carbonitrile奉，6benzyloxyindole一3carbonitrile木，7benzyloxyindole一3一carbonitrile木；(3)4一fluoroindole一3carbonitrile棗，5fluoroindole3一carbonitrile，6fluoroindole一3一carbonitrile木；(4)4一c

4、hloroindole3一carbonitrile木，5chloroindole一3一carbonitrile木，6chloroindole3一carbonitrile木，7chloroindole3carbonitrile宰；(5)4bromoindole3carbonitrile棗，5bromoindole一3一carbonitrile，6bromoindole3carbonitrile；(6)Methyl3cyanoindole4

5、carboxylate，methyl3cyanoindole5carboxylate冰，methyl3cyanoindole一6一carboxylate，methyl3cyanoindole7carboxylate；(7)3，4dicyanoindole木，3，5dicyanoindole宰，3，6dicyanoindole串；AndfourcompoundsofNacetylsubstitutedindole3carbonitrile

6、alsohavebeensynthesizedThereareNacetyl5一methoxyindole一3一carbonitrile水N—acetyl一5一benzyloxyindole一3一carbonitrile水，N—acetyl一6benzyloxyindole一3一carbonitrile木andmethyl1acetyl一3一cyanoindole一5carboxylateThe21newcompoundswithsup