微波輻射條件下小分子雜環(huán)化合物的合成研究.pdf

1、西北師范大學(xué)碩士學(xué)位論文微波輻射條件下小分子雜環(huán)化合物的合成研究姓名：劉娟申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：有機(jī)化學(xué)指導(dǎo)教師：王喜存20050501ABSTRACTThispaperisdividedintosixchaptersChapterone25disubstituted13，4一oxadiazolesarewidelyusedintheindustryofmedicineandmaterialbecauseoftheirwidespec

2、tmmofbiologicalandopticalactivitiesThenewmethods，newreagentsandnewtechnologies，suchaspolymersupportedorganicsynthesis，microwaveirradiationandsolventfreereaction，ofsynthesisof25一disubstituted13，4oxadiazolesarereviewedinth

3、ischapterChaptertwoAseriesofsubstituted13，4一oxadiazoles[iresynthesizedbycyclizationofseveralacidswitharoylhydrazinesinthepresenceofapolymersupposedcyelizingagentunderthesolventfreeandmicrowaveirradiationconditionsWestudi

4、eddifferentaffectsofvariesconditions(ratios，solvent，catalysts，irradiationpowerandtime)onthereactionsThenwesynthesized36new2，5disubstituted13，4oxadiazolesThefluorometricspectrumofsomecompoundsisanalyzedChapterthree12，4tri

5、azolo[3，4糾1，3，4thiadiazolederivativeshaverepresentedaninterestingclassofcompoundspossessingawidespectrumofbiologicalactivities，sincetheycombinedtwobioaetivesubstructure，12，4triazoleand13，4thiadiazoleThischapterhasdescrib

6、edthecharacterization，biologicalactivitiesandnewsynthesistechnologyofthe12，4一triazolo[3，46】1，3，4thiadiazolederivativesChapterfourThekeysynthon3【5aryl2furanyl]4amino一5mercapto—striazolewaspreparedbytwostepreactionderivedf

7、rom5aryl2furanylcarboxylicacidhydrazideundermicrowaveirradiationThereactionsof3【5aryl一2furunyt]4amino一5一mercaptoStriazole謝tharylcarboxylicacid，aryloxyaeeticacidafford8new3f5’mnitrophenyl2’furanyl)6arylS—triazolo[3，4，b]一1

8、，3，4thiadiazoles，9new3(5’pchlorophenyl2furanyl)一6aryloxystriazolo[34b】1，3，4thiadiazolesrespectivelyConsiderableincreaseinreactionratehasbeenobservedwithimpmvedyieldsundermicrowaveirradiationChapterfiveThioureasandthiosem

9、icarbazideshaveextensivebiologicalactivities，suchasantibacteryantihypertension，anticonvulsive，antidepressant，fugicide，insecticide，herbicideandplantgrowthregulatoractivitiesThereforetheyhavebeenappliedtomanyfields，forinst