槲皮素衍生物的合成研究.pdf

1、山東師范大學碩士學位論文槲皮素衍生物的合成研究姓名：魏素梅申請學位級別：碩士專業(yè)：有機化學指導教師：劉玉法20090405山東師范大學碩士畢業(yè)論文AbstractQuercetinbelongstoanextensiveclassofpolyphenolicflavonoidcompounds，frequentlyoccursasglycosideQuercetinanditsderivativesactionsincludeantia

2、rrhythmia，anti—bloodplatelet，antioxidant，anti—canceragent，andexpandbloodvesselhadbeenreportedQuercetinanditsderivativeshadbeenattentioninbiologicalvaluerecently28Quercetinderivativesweresuccessfullysynthesized，including2

3、3newcompoundsTheirstructureswerefullycharacterizedbyelementalanalysis，IR，1HNMR，13CNMRandMSspectroscopiesDissertationalsosuccessfullydeterminesuperoxideanionfreeradicalactiontoquercetinderivativesanditscomplexsThemainresu

4、ltsaleasfollows：1Therecentresearchprogressofquercetinderivativesreceptors，includingdesign，chemicalsynthesisandtheirapplicationsinthefieldsofpharmacologicalactivities，wasbrieflyreviewedForquercetinanditsderivativeshavewel

5、lidentityitisanimportantpracticalvalueonthedesignandsynthesis25compoundsinvolving3unreportedquercetinderivativesweresuccessfullysynthesizedtouserutinandtri(一Ohydroxyethyl)rutinasrawmaterialTheirstructureswerefullycharact

6、erizedbyIR，1HNMR，”CNMRandSOon3ThefirstexampleofY4’，7tri(O—hydroxyethyl)quercetinastherawmaterial，10newquercetinderivatives(L17～LIO)weresuccessfullysynthesizedviatheetherificaionreaction4Design，synthesis13quercetinanditsd

7、erivative—metalcomplexes，10complexesisunreportedFindtosynthesizethequercetinderivative—metalcomplexes，besidesthetemperatureofreactionsystemandthereactiontime，thepHvalueofreationsolutionwaskeyfatorfortheformofcoordination

8、complexsTheinhibitoryeffectofquercetinderivativeanditscomplexesonsuperoxideanionfreeradical，wastestedbypyrogallolauto—oxidationsystem，showingthegoodcooperativeactionbetweenquercetinderivativesandtracemetalelementsTheresu