2-甲基吡嗪-5-羧酸的合成及工藝優(yōu)化.pdf

1、天津大學(xué)碩士學(xué)位論文2甲基吡嗪5羧酸的合成及工藝優(yōu)化姓名：顧豪輝申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：馮亞青20070601ABSTRACT2Methylpyrazine5carboxylicacidisakindofimportantmedicinalintermediate，mainlyusedforsynthesizingthesecondgenerationsulphonylureashypoglycemicagent，ne

2、wgenerationlongeffectblood—lipidloweringdrugandthemedicineusedtOefficientlytreatbacillaryphthisisTheprocesstOsynthesize2methylpyrazine5carboxylicacidusing2，5一dimethylpyrazineasrawmaterialandpotassiumpermanganateasoxidant

3、wasstudiedinthisthesisFirstonthebaseofthepreviouswork，theoptimalreactiontemperature，reactiontime，feedingtimeandtheoptimalfeedingratiowereobtainedbythemethodofliquidfeedingTheyieldoftheproductWas4315％Andthepuritywas9612％T

4、osolvetheproblemthatthepotassiumpermanganatehasbadsolubilityinwater，themethodofsolidfeedingWasstudiedandoptimizedTheyieldreached4172％AndthepurityWas9775％。Bycomparingwi也onceacidificationmethod，twiceacidificationmethodgave

5、higherpurityproductTosavethecost，theunreacted2，5dimethylpyrazineWasrecycledandtheyieldoftheproductintotalincreasednearly30％Andtheoptimalreactiontemperaturewas70“C，optimalreactiontimeWas2handfeedingmolarratioofpotassiumpe

6、rmanganateto2，5dimethylpyrazinewas2Theyieldof也eproductwasabove75％Theoverallyieldof2methylpyrazine5carboxylicacidWaS61％andthepurityreached99％afterrecrystallization，whichWasinaccordwiththestandardofmedicineintermediateandh