MMP-2及CD105在唾液腺腫瘤中的表達及意義.pdf

1、山西醫(yī)科大學碩士學位論文MMP2及CD105在唾液腺腫瘤中的表達及意義姓名：蘆楊申請學位級別：碩士專業(yè)：口腔臨床醫(yī)學指導教師：齊鴻亮20100415山西醫(yī)科丈學碩L學位論文TheexpressionofmatrixmetaUoproteinase2andendoglininsaliVaryglandtumorsAbstractobject：Inthisstudy，usingimmunohistochemicaltechniquetode

2、tecttheexpressionandmutualcontactsofMMP一2andCDl05intheno衄altissue觚dVarioustumortissuesofsaliVar)r舀aIlds，andthanillVestigationtheirrolesininVasionandmetastasisofthemalignantsaliVary酉andtlImOrSMethods：Subjectsselected舶mthe

3、archivedpamffin—embeddedsaliVary酉andtumorswhichweresu蟛calexcisionbyoral觚dmaxillof她ialsu瑪eryofFirstHospitaIofShanXiMedicaluniVe璐itybytheyear2005，1—2008，12(8casesofsaliVary酉觚dno肋altissue，10c嬲esofbeIljgntissue，42c弱esofmalig

4、nanttissue)IlIlmunohistochemist巧methodwasusedtomeasuretheexpression柚dloCalizationofMMP一2andCDl05intissuesofsaliVa巧百and，calcuIation0fMVDValues強dMMP一2scoreresults，thedataw鶴鋤alyzedbySPSS13Oso腳arcResults：Inourstudyweusetheme

5、thod0fimmuIlohistochemistrytomeaSuretheexpressi蚰姐dlocalizationofMMP2aIldCDl05ill8casesofsaliVaryglaIldno咖altissue，10casesofpleomo印hicadenoma(PA)tissue，20cases0fadenoidcysticcarcinoma(ACC)tissuc，6cases0faciniccenc缸cinoma(

6、ACC)tissue，10casesofcarcinomaeXpleomo叩hicadenoma(CPA)tissue，6casesofmucoepide咖oidcafcinoma(MEc)tissueIIlourstudywefoundthat：1)TllediflbrenceofMMP2scoreresultsbet、)IreensaliVar)，酉鋤dnomaltissue，plcomo印hicadenom碼adenoidcyst

7、icca∞iIlom如aciniccen黜inoma，cardnomainpleomo印hicadenom毛mucoepidemoidcarcillomawassi印ificant(H=42406，P0001)；nedi骶rencesofMMP2scoreresultsbe倆eendi骶renttypes0fpatholo西cal柚dsizesofthetissuesofadenoidcysticcarcinomaweresi鰣fic鋤

8、t鐘=8571，P=o011；礦=7363，P=o017)，thedifferencesbe觚eensex，age，tllmorlocationsite，availabilityofneurolo西calsymptomsandTNMgrouping’sofMMP2scorecontmstwerenotsi目ificant2)TheresultsofMVDValuestaggedbyCDl05insaliVar)，酉andtissueaI

9、ldV撕oustypesoftumo娼werc：saliVary百andno姍altissue(0875o8345)，pleomorphicadenoma(1670059638)，adenoidcysticcarcinoma(47250181365)，aciniccellcarcinoma(5400050596)，carcinomaexpleomo叩hicadenoma(45600145312)，mucoepidermoidcarcin

10、oma(4333340332)，byKruskal—wallistest，thedifferencewassignificant(H=38376，PO001)；neC0untsofMVDshowedsi齲ificaIltcorrelationwithsizeofthetissues，stage0fthedise弱e，typeofpatholo西calandneurolo西calsymptoms(t=3550，p=O002；t=2170，

11、p=0044；t=2389，p=O028；t=3096，p=0006)，thedi骶rencesbet、)Ireensex，agesandtumorsh斌edillwherewerenotsi印if：icant3)Inadenoidcysticcarcinoma，thedi低rellce0fMvDValuewhichwasdiVidedbytheMMP2scoreresultswassi印ificant(t=3763，P=0001)11