大腸癌組織中EphA2蛋白的表達及其與E-鈣粘蛋白的關系.pdf

1、青島大學碩士學位論文大腸癌組織中EphA2蛋白的表達及其與E鈣粘蛋白的關系姓名：郭春霞申請學位級別：碩士專業(yè)：內(nèi)科學（消化系?。┲笇Ы處煟黑w清喜20080529RELATIoNSHIPBETWEENTHEEXPRESSIONOFEPHA2ANDE—CADHERINANDITSSIGNIFICANCEINCoLoRECTALCARClNoM【AAbstractobjectiveToanalysetheroleofEphA2proteina

2、ndEcadherinproteinincolorectalcarcinomawedeterminedtheexpressionofEphA2proteinanditsrelationshipwithEcadherinproteinincolorectalcarcinomaandinvestigateitsclinicalsignificanceMethodsTheexpressionofEphA2andEcadherinin67cas

3、esofcolorectalcarcin。omaand28casesofnormallargeintestinetissuesweredeterminedbyimmunohistochemicalanalysis(SPmethod)Results(1)thepositiveexpressionofEphA2proteinwerefoundin6119％(67cases，41／67)colorectalcarcinoma，2857％(28

4、cases，8／28)normal1argeintestinetissuesTherewasasignificantcorrelationbetweencharacteristics，suchtheobservedexpressionandsomeclinicalandpathologicalashistologicalgrade，invasivedepth，lymphnodemetastasisandhematogenousmetas

5、tasis(PO05)(2)thepositiveexpressionofEcadherinproteinwerefoundin4627％(67cases，31／67)colorectalcarcinoma，100％(28cases，28／28)normallargeintestinetissuesTherewasasignificantcorrelationbetweentheobservedexpressionandsomeclin

6、icalandpathologicalcharacteristics，suchashistologicalgrade，invasivedepth，lymphnodemetastasisandhematogenousmetastasis(P005)(3)thepositiveexpressionofE—cadherinproteinwaslowerinthegroupcofEphA2proteinpositiveexpressiontha

7、ninthegroupofEphA2negativeexpression(尸O01)。ConclusionThecolorectalcarcinomawasdevelopedviadifferentpathwayTheexpressionofEphA2andEcadherinmaybeinvolvedinthedevelopmentandprogressionofcolorectalcarcinomatogether；andcombin

8、edmeasurementofthesetwoproteinsmaybeausfulmeasureforthedeterminationofmalignantdegreeandtheprogressofcolorectalcarcinomaTheexpressionofEphA2proteinwasnegativelycorrelatedwiththelossofEcadherinproteinPostgraduatestudent：G