貴州省部分地區(qū)婦女宮頸人乳頭瘤病毒感染現(xiàn)狀調(diào)查及分析.pdf

1、遵義醫(yī)學(xué)院碩士學(xué)位論文貴州省部分地區(qū)婦女宮頸人乳頭瘤病毒感染現(xiàn)狀調(diào)查及分析姓名：婁雪玲申請學(xué)位級別：碩士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：孫麗君20100501遵義醫(yī)學(xué)院碩十學(xué)位論文貫州省鄢分地區(qū)婦女富頸人乳火廂炳霉感染現(xiàn)狀調(diào)奩及分析mAnInveStl2atlOnofhumanpapillomavirusinleCtlOninwomen’s●_●●一__l■●^●●●cervixesinpartareasofG11izhouProvinceAb

2、stract：Objective：Toinvestigatethedistributionofdifferenthumanpapillomavirus(HPV)subtypeinfection雒well嬲highriskfactorsinwomen’ScervixesinsomeareasofGuizhouProvince，thereforeoffersomeevidencesforthepurposeofpreventingand仃e

3、atingcervicalcancerasfwellasforfurtherdevelopingandusingofcervicalcancervaccineinthisregionMethod：Atotalof2339womenhavingsexuallifewerecheckedin21HPVgenotypesbyDNAflowthroughhybridizationgenechiptechnique，nesubjectswered

4、efinitelydiagnosedbythe3stepdiagnosticmethodsofcervicalcancerscreeningindepartmentofGynecologyandObstetricsbetweenDecember2007toDecember2008，severalhospitalswereinvolvedinthisstudy嬲follows：affiliatedHospitalofZunyiMedica

5、lCollege(745cases)，GuizhouProvincialPeople’SHospital(769cases)，QiannanstateHospital(467cases)，andTongrendistricthospital(358cases)Results：1TOtalrateofHPVinfectionWaS3031％(709／2339)inthe2339womenmtopfivesubtypesofHPVinfec

6、tionwereHPVl6，52，18，58and11genotype，andtheaccordenceinfectionratewere987％(231／2339)，564％(132／2339)，495％(116／2339)，419％(98／2339)and299％(70／2339)respectively2‰topfoursubtypesofHPVinfectionwereHPVI6，52，18and58genotypeinalll

7、evelsofcervicaldiseases3366ofCINpatientsand181patientsofinvasivecervixcarcinoma(ICe)werediagnosedthroughpathologticexaminationTherateofHPVinfectioninCINI，C玳II，CINIIIandICCwere3426％(74／216)，7778％(56／72)，8205％(64／78)and779

8、％(141／181)respectively(rsO999，P001)4ThepeakofHPVinfectionrangedfromageof31to35and56to60yearsoldThcearlierthefirstsexuallife，thehighertheHPVinfection(tendency／test，PO05)5Amongthe1811ccpatients，therateofHPVinfectionwere845

9、2％(131／155)insquamousc跚cinomaofthecervix(scc)and3846％(10／26)inadenocarcinomaofuterinecervix(AUC)ICCpatientsweremainlyinfectedbyHPV16，18genotypein181cases111eproportionofHPVl6infectionwas6183％(81／131)inSCCandHPVl8infectio