實(shí)驗(yàn)性鵝銅中毒機(jī)理研究.pdf

1、西南大學(xué)碩士學(xué)位論文實(shí)驗(yàn)性鵝銅中毒機(jī)理研究姓名：鄧科敏申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：臨床獸醫(yī)學(xué)指導(dǎo)教師：李前勇20080601AbstractStudiesonPathogenesisofExperimentalCopperIntoxicationinGeeseMaster0fClinicalVeterinary：KemiTi，DengSuperVisor：AssociateProfQianyong，LiAbstraCt240one—day—

2、oldSichuanwhitegeeseweredi、ridedrandomlyintothree鏟oups，andfedondietwithCuof1O24mg瓜gincon仃olgroup，Cuof400mg／l(gincoppertoxicgmupIandCu0f600mg／l(gincoppertoxic鏟oupIItostudyefrectofcoppertoxicityono唱ansandsomebloodparameter

3、singeesefor40days，陀spectivelyTheexpressionofC似lgeneITl】RNAingeeseliverofdifrerentgroupswerestudiedbymemethodofImPCRattheendoftest，tostudythepamogenesisofcopperintoxicationingeeseTWogroupsofcopperintoxicationshoweddistinc

4、tiveclinic“signs，andthedeathwere叩tomehighestpeaaRerabout30daysTlleresultsshowedthat，coppertoxicwassensitivetogeeseabout30daysTheincidenceofc叩pertoxicgro叩1was50％，aIldcoppertoxicgroup11was100％，themortalityinmetwo伊oupscould

5、respectiVelyreach30％鋤d80％atmeendoftestTIleresearchofpathomorphologyshowedsilTlilarlesionsinthe帆ocoppertoxicgroupswhencomparedwithcontrol黟oupThecuticleofgizzardappeared也ickeningaIldcrack；ThedigestiVe臼actwas凡llofⅡleblackbr

6、ownorcoppe卜greensubstance，Theintestinalmucosawasswelledandflush’andthesubmucosashowedmodified，necrosisandexfoliation；Histopathologically，thehepatocellularrenaltubulesaIldcardiacmusclemainlyshowed孕anularaIldvacuolardegene

7、ration；Resultscomparedwithcon仃01group，thecontentofcopperjn1iVerandbloodwasincreasedremarkably；respectiVely；ChangesofHaematologicalIIldexesshowedmatredbloodcellsincoppertoxicgroupIandcoppertoxicgroupIIbec鋤edefonned，degene

8、ratedandwefeenla唱edorshrirll(ed，or／andnecroticThepopulationsofredbloodcells，hemoglobincomentsweremuchlowerthanmecon的l伊oupIIladdition，mesemmLactateDehydrogenase(LDH)，glutamicoxaloacetictms鋤inase(GOT)，glutamicpymVic仃ansanl