局部晚期食管癌同步放化療和序貫放化療的臨床分析.pdf

1、中國醫(yī)科大學(xué)碩士學(xué)位論文局部晚期食管癌同步放化療和序貫放化療的臨床分析姓名：田欣申請學(xué)位級別：碩士專業(yè)：腫瘤學(xué)指導(dǎo)教師：吳榮20090301英文結(jié)構(gòu)式摘要Sequentialandconcurrentchem一radiotherapyforpartlyadvancedstageesophagealcarcinomaobjectiveToobservethecurativeeffectandtoxicityofsequentialandc

2、oncurrentchem一radiotherapybasedonPFprogram(5FUDDP)forpartlyadvancedstageesophagealcarcinomaMethodDiagnosedbypathologicaland／orcytology，the64patientswererandomizedintothefollowingtwogroupsTheconcurrentgroup：thechemotherap

3、yWasadministeredalongwi廿ltheradiotherapyThesequentialgroupWasfirstgivenchemotherapy(Fluorouracil(5FU)500me；／m2ondaysl～5andcisplatin(DDP)20me／m2days15forevery28days)for4cyclesandfollowedbyradiotherapyResultsTheoverallresp

4、onse(CRPR)rateWas9118％fortheconcurrentgroupand7000％forthesequentialgrouprespectively(P005)The1yearand2yearsurvivalrateswere7941％、6000％forconcurrentgroup，5294％、3000％forsequentialgroup；Thetotaltimethetwogroupsneedsforthetr

5、eatmenthavestatisticsdifference(PO05)Themajortoxiceffectsincludinghematologictoxicityesophagitisandnausea、emesiswereobserved，butonlyhematologictoxicityhadsignificantdifferencebetweenthetwogroups(PO05)Conclusionsequential

6、andconcurrentchemradiotherapybasedonPFprogram(5一FUDDP)forpartlyadvancedstageesophagealcarcinomaissafeandeffectual，theconcurrentgroupshortenthetotaltimeforthetreatment，althoughthetoxicitylargeritistolerableSoitisworthclin