兒童肥胖與頸動脈內膜-中層厚度及動脈內皮功能的相關性研究.pdf

1、浙江大學碩士學位論文兒童肥胖與頸動脈內膜中層厚度及動脈內皮功能的相關性研究姓名：李萌霞申請學位級別：碩士專業(yè)：兒科（心內科）指導教師：朱衛(wèi)華龔方戚20050301浙江大學碩士學位論文AbStractBackgroundEndothelialdysfunction(measuredasreducedflowmediateddilatation，FMD)andthickeningofthearterialintima—medialayer(

2、IMT)areearlyindicatorofatherosclerosisinadultsandCallalsobedemonstratedinchildrensufferingfromdiabetesandgeneticdisordersoflipidmetabolismThereisapaucityofdata，however，onwhetherearlyatheroscleroticalterationscanbeinduced

3、andpromotedbychildhoodobesityAstheincreasingprevalenceofobesityinchildrenisanimportantpublichealthissueinChinaandabroad，westudiedultrasonographicsignsofearlyartherosclerosisinrelationtoestablishedriskfactorsofcardiovascu

4、lardiseaseinagroupofobeseChinesechildren，comparedwithcontr01MaterialsandMethodsFortythreepatientswithpurechildhoodobesity(bodyweightexceeding20％standardbodyweightorbodymassindex24)werecomparedtoagroupof28healthycontrolsB

5、othgroupsdidnotshowsignificantdifferencesinage，genderratioandbodyheightIMT，FMD，carotidhemodynamicparametersandbiochemicalmarkersofdyslipidemiaweremeasuredandanalysedinrelationtosubjectcharaeteristicsPredictorsofincreased

6、IMTandreducedFMDwereidentifiedwithmultifactorlinearregressionResultsObesechildrenshowedsignificantlyhighersystolicanddiastolicbloodpressureandelevatedlevelsoftotalcholesterol，LDLcholesterol，triglyceridesandApolipoprotein

7、BCarotidIMTwassignificantlyincreased(O62mmvs046mm，p0001)andflow—mediateddilatationwasmarkedlyreduced(109％vs188％p0001)intheobesitygroup，compared、vimcontr01StatisticalsignificancepersistedafteradjustmentofIMTandFMDforbodym

8、assindex03MI)onANCOVAOnstepwiselinearregression，BMlwasfoundtobethestrongestpredictorofincreasedIMTandreducedFMD，whilebodyweight，bloodpressure，totalcholesterol，LDLcholesterolandApoBwerealsopositivelycorrelated(allPO01)Bil

9、ateralIMTmeasurementsinthecommoncarotidarteryandintheinternalcarotidarteryofobesesubjectsallshowedsignificantlyincreasedIMTwimahighcorrelationofallmeasurementssuggestingthatintimamediathickeningisasystemicprocessinvolvin