卵巢早衰與細胞因子TNF-α,EGF和IL-2的相關(guān)性研究.pdf

1、新疆醫(yī)科大學碩士學位論文卵巢早衰與細胞因子TNF-α,EGF和IL-2的相關(guān)性研究姓名：韓寧寧申請學位級別：碩士專業(yè)：臨床檢驗診斷學指導(dǎo)教師：張朝霞2009-04新疆醫(yī)科大學醫(yī)學碩士學位論文 新疆醫(yī)科大學醫(yī)學碩士學位論文 —2—Analysis of cytokines TNF-α，EGF and IL-2 in patients with premature ovarian failure Postgraduate:Han Ning

2、ning Supervisor: Prof. Zhang Zhaoxia Abstract Objective: To investigate the analysis of cytokines TNF-α、EGF and IL-2 in patients with premature ovarian failure(POF). In order to explore the diagnosis and treatment of PO

3、F. Methods: Seventy patients with premature ovarian failure and twenty patients with nomal control were evaluated from 2006 to 2008. Serum anti-ovarian antibodies (AoAb) were detected by ELISA. Sera EGF and IL-2 level w

4、ere measured by immunoradio-metric assay(IRMA) and TNF–α was measured by radio-immunoassay (RIA), respectively. Results: There had no significant difference between patients with POF and patients with normal controls in

5、age distribution and the average of age (P>0.05). Patients with POF had higher AoAb level, and lower TNF-α、EGF or IL-2 level than normal controls (all P<0. 05) . The levels of the cytok ines (TNF-α、EGF and IL-2) in

6、 the sera from POF patients with positive AoAb were significantly higher than those of the POF patitents with negative AoAb （P<0.05） . Conclusion: Autoimmune POF takes a quite proportion in POF. TNF-α、EGF and IL-2 pla