超排卵周期血管內(nèi)皮生長因子、胰島素樣生長因子-Ⅱ與妊娠結(jié)局的關(guān)系.pdf

1、石河子大學(xué)碩士學(xué)位論文超排卵周期血管內(nèi)皮生長因子、胰島素樣生長因子Ⅱ與妊娠結(jié)局的關(guān)系姓名：朱明玥申請學(xué)位級(jí)別：碩士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：瑪依努爾尼牙孜20080601超排卵周期Jf『L管內(nèi)皮生長因子、胰島素樣生長岡予一lI與妊娠結(jié)局的關(guān)系A(chǔ)bstractObjective：Bydetectingtheconcentrationofvascularendothelialgrowthfactor(VEGF)andinsulinlikegr

2、owthfactorII(IGFII)inthetreatmentofinfertilityinpatientsonthedayofretrivingoocyteserumandfollicularfluidinvitrofertilizationandernbryotransplantation，Tostudyontherelationbetweenvascularendothelialgrowthfactor(VEGF)、Insul

3、ikegrowthfactor(IGFII)andtheovarianresponse、theoutcomesofembryotransferinIVFfcmalesMethods：Sixtyovulatorywomenwithinfertilitycausedbyunknownoriginortubalfactorwereincludedinthisstudyfrom20067to20081Thegonadorelinantagoni

4、stprotocolwasoperatedinIVFcyclesGranulosacellswereobtainedfromfollicularaspiratesduringoocyteretrievalAccordingtothenumberofoocyteretrieval，thepatientsweredividedintothreegroups：highresponders(oocytes=14)，normalresponder

5、s(oocytes413)andpoorresponders(oocytes=3)ThereisnoagediferenceinthreegroupsBloodsampleswerecollectedbeforethedayofinjectingFSH，onthedayofinjectinghCGonthedayofretriveingoocyte，F(xiàn)ollicularfluidswereobtainedonthedayofretriv

6、eingooc”e，TheVEGFconcentrationsofallspecimensweremeasuredbyELISA，TheIGF—IIconcentrationsofallspecimensweremeasuredRI，AndrecordedtheoutcomeofernbryotransferResults：1Duringtheprogramofcontrolledovrianhyperstimulation，theVE

7、GFconcentrationbecamegraduallyhigherMongwiththedevelopingoffolliclesandcametohigherlevelonthedayofoocytesretrival2TheVEGFconcentrationsweredifferentindifferentrespondersofcontrolledhyperstimulation(COH)TheVEGFconcentrati

8、onsinserumoflowresponderswerelowerthanthatoftheothers(pO05)AllthepatientsinthefollicularfluidweresignificantlylowerthanthatofIGFIIlevelsinperipheralblood3ThegoodembryosrateswerehighintheoocyteswithhighFFVEGFconcentration