鹽酸苯達(dá)莫司汀及其衍生物的合成與表征.pdf

1、南昌大學(xué)碩士學(xué)位論文鹽酸苯達(dá)莫司汀及其衍生物的合成與表征姓名：張勝菊申請學(xué)位級別：碩士專業(yè)：有機化學(xué)指導(dǎo)教師：戴延鳳魏俊超20100611ABSTRACTABSTRACTChroniclymphocyticleukemia(CLL)isadiseaseofclonesproliferationofmalignantB—cellwhichcausedbyapoptosisItisshowedthatmaturesmalllymphocyt

2、esaccumulateexceptionallyinperipheralblood，bonemarrowandotherlymphoidtissuesHoweverthepathogenesisofCLLisstillnotfullyunderstoodAtpresent，therearethreemainwaysforthetreatmentofCLL，suchas：radiationtherapychemotherapyandau

3、tologousstemcelltransplantationChemotherapyconsistsofSsingledrugchemotherapycombinedchemotherapyandmonoclonalantibodiesandchemicalimmunotherapyBendamustinehydrochlorideisacompoundofcontainingpurineanalogueandalkylatingag

4、entsthatCandestroytheDNAinsideoftumorcells，whichinducingeellapoptosisItisforthetreatmentofthecasesthatCLLCan’tbecuredbyfirstlinetherapyofchlorambucilandtheinertBcellnonHodgkin’Slymphomathatdiseaseprogressin6monthsbyritux

5、imaborprogramwimrituximabThepurposeofthisresearchtopicistoimprovetheBendamustinehydrochloridesyntheticrouteandsynthesissomenewanaloguesThemaincontentsareasfollows：Chapterl：ThischapterdescribesthecurrentstageofCLLstherapy

6、theprogressoftreatment，aswellashydrochloricacidBendamustinecurrentdevelopmentstatusandclinicaleffectsChapter2：Atthispart，1wanttodesignanewsyntheticrouteofBendamustinehydrochloridebasedontheanalysisofexistingsyntheticrout

7、e，andthensyntheseChapter3：SynthesizefournewanaloguesofBendamustinehydrochlorideTheirkeyintermediatesandtargetcompoundsarecharacterizedby1HNMR‘’CNMRIRMSThefourcompoundsareasfollow：1：4一1一ethyl一5NN【bis(2chloroethyl)一amino]2

8、一benzimidazolyl一butyricacid；2：3一1ethyl5NN一[bis一(2’一chloroethyl)amino]2benzimidazolyl一propionicacid；3：3[1一phenyl一5N，N—Ibis(2’一chloroethyl)一amino]一2一benzimidazolylpropionicacid；4：3一【1methyl5N，N一[bis一(2’chloroethyl)amino]一2