環(huán)氧化酶-1在乳腺癌中的表達(dá)及其與腫瘤血管形成的關(guān)系.pdf

1、溫州醫(yī)學(xué)院碩士學(xué)位論文環(huán)氧化酶1在乳腺癌中的表達(dá)及其與腫瘤血管形成的關(guān)系姓名：尤捷申請學(xué)位級別：碩士專業(yè)：腫瘤學(xué)指導(dǎo)教師：郭貴龍陳國榮20080501溫州醫(yī)學(xué)院碩士學(xué)位論文TheRelationshipBetweenCyclooxygenase一1ExpressionandTumorAngiogenesisinHumanBreastCancerAbstractobiective：Tostudytherelationshipbetween

2、cyclooxygenase1(cox1)expressionandtumorangiogenesisinhumanbreastca／ice]Method：61breastcancer’sspecimenwereanalyzedforCOX1andvascularendothelialgrowthfactor(VEGF)expressionsbyimmunohistochemistryusingspecificmonoclonalant

3、ibodiesWeexaminedthemicrovasculardensity(MVD)，usingCD34stainingbyimmunohistochemistryResult：TherateofCOX1postiveexpressionbreastCallceris607％(37／61)AsignificantcorrelationWasfoundbetweenCOX1andVEGFexpressions(P=0007)Both

4、COX一1andVEGFweresignificantlycorrelated、航mMVD(P005andP001)TheCOX1positiveexpressionwasassociatedwithsmallertumorsizeandstageIConclusion：Hi曲expressionofCOXolexistsinbreastcarcinomaCOX1isrelatedtotumorangiogenesisinbreastc

5、ancer’especiallyinearlystageItislikelythatVEGFisoneofthemostimportantmediatorsoftheCOX1angiogenicpathwayTheresultsconfirmedtheeffectofNSAIDontheprophylaxisofbreastcancel[Keywords]cyclooxygenase一1；breastneoplasma；vascular