血管內(nèi)皮生長因子和微血管密度在大腸癌中的表達及其臨床意義.pdf

1、蘇州大學碩士學位論文血管內(nèi)皮生長因子和微血管密度在大腸癌中的表達及其臨床意義姓名：候健申請學位級別：碩士專業(yè)：普通外科學指導教師：高敏王建中2002.1.1J『!笪塑些蘭【三型：|=塑垡坐笪!!f生i叁墮塑!塑耋些絲些墮堡堂蘭———————————————蘭!!!蘭AbstractObjective：Quantificationoftumoranglogenesishasbeenrecentlynoticedintumorgrowth，

2、metastasisandinvasion，andbecomea“hotspot”inturnerresearchfieldAngiogenesishasbeenprovedessentialforturnergrowth、invasionandmetatasis，suchasbreastcarcinomagastriccancer、livercancerandSOonButtherearefewstudyoftheroleofangi

3、ogenesisincloerectalcancerIt’SroleisstillcontroversialMethod：Expressionofvascularendothdialgrowthfactor(VEGF)andmircovesseldensitylevelsweremeasuredin160patientswithcolorectalcancer，andcorrelationwithpathologicalparamete

4、rswasanalysedResults：In160colorectalcancerpatients，VEGFimmunoreactivit5’waspositivein73(weakin16，intermediatein25，andstrongin32)ThegradeofpositivityagainstVEGFwassignificantlyhigherwithadvancedstagesofthedisease(Duckesst

5、age)(P001)TheexpressionlevelofVEGFinprimarycancerwithlymphnodemetastasiswassignificantlyhigherthaninthosewithoutlymphnodeinVolVcment(pO01)Thesameresultswerealsofoundinprimarycancerwithlivermetstasisthanthoseinprimarycanc

6、erwithoutlivermetastasisNosignificantcorrelationwasfoundbetweenVEGFandtumorsize、differentiatedstagePositi、7ecorrelationwasfoundbetweenMVDandVEGIexpressionHighMVDwasassociatedwithlymphnodemetastasis、Dukesstageandlivermeta

7、stasisConclusion：TheresultssuggestthatVEGFandMVDmayinvolvedintheDukesstageandmetastasisofthecolerectalcancer、andthathigherexpressionlevelofVEGFandMVDpredictmetastasisofthetumorandpoorprognosisofthepatientsKeywords：Colere