聯(lián)合檢測腫瘤標(biāo)志物在肺癌診斷中的臨床價(jià)值.pdf

1、石河子大學(xué)碩士學(xué)位論文聯(lián)合檢測腫瘤標(biāo)志物在肺癌診斷中的臨床價(jià)值姓名：許杰申請學(xué)位級別：碩士專業(yè)：外科學(xué)指導(dǎo)教師：彭心宇20080501AbstractObjectiveTostudytheclinicalvalidityofcombinedmeasurementoftumormarkersindiagnosticevaluationoflungcancer—Meth—odsSerumlevelsofCEA，NSE，CYFRA211，Pr

2、oGRP，M2PKweremeasuredbyELISAin62patientswithlungcancer40patients謝tllbenignpulmonarydiseasesand20healthysubjectsandanalyzed—Res—ults(1)Section5oflungCanCerserumtumormarkers(CEA、CYFRA21一l、NSE、M2PK、PROGRP)weresignificantlyh

3、igherthanthatbenignpulmonarydiseasegroupandthenormalcontrolgroup(P005)。(2)Theresultsshowedthat，forbenignandmalignantlungdiseasesandlungdifferenthistologicaltypesoflungCanCer，thetumormarkersexpressdifferently。CEAinpatient

4、s謝mlungadenocarcinoma，theseroprevalencewashigh(889％)SquamouscarcinomaofthelungthesensitivityofCYFRA211Was686％ItisstatisticalsignificancethatCEAinpatientswimadenocarcmoma(2730士943ng／m1)ofthelungcomparingwimtheseroprevalen

5、ce(13174835ng／m1)(P005)AnditisalsostatisticalsignificancethatCYFRA21—1inpatients、)l，itllseroprevalence(12044598ng／m1)ofthelungcomparing、)I，iththeadenocarcinoma(8304288ng／m1)(P005)InlungcancerthetumormarkersNSE、ProGRP、M2一

6、PKexpressionhasnostatisticalsignificancebycomparingseroprevalencewithadenocarcinoma。(3)netunlormarkersexpressdifferentlyintumorstage。孔eexpressionofTMCEA、CYFRA211、NSE、M2PKincreasewiththeincreaseoftumorstagerPO05)AndPRoGRP

7、instageIVwashigherotherthreestage(4)ByParalleltheSensitivityofCEANSE、CEACYFRA211、NSECYFRA211、CEANSECYFRA211were721％、824％、733％、889％，andtheSpecificwere957％、707％、725％、601％。howeverbySeriestheSensitivityofCEANSE、CEACYFRA211、N

8、SECYFRA211、CEANSECYFRA211were177％、575％、323％、177％，andtheSpecificwere100O％、975％、1000％、1000％?！狢—o—n—c—lu—s—i—o—n—CombinedmeasurementofmultipleserumtUlTIOrmarkerssignificantlyincreasesthediagnosissensitivityInaddition，itisal