HBME-1、Galectin-3和CD44v6在甲狀腺濾泡癌與不典型腺瘤中的表達及意義.pdf

1、新疆醫(yī)科大學碩士學位論文HBME1、Galectin3和CD44v6在甲狀腺濾泡癌與不典型腺瘤中的表達及意義姓名：任俊奇申請學位級別：碩士專業(yè)：病理學與病理生理學指導教師：尼加提熱合木201004新疆醫(yī)科大學醫(yī)學碩士學位論文新疆醫(yī)科大學醫(yī)學碩士學位論文—2—TheexpressionsignificanceofHBME1、Galectin3CD44v6infollicularthyroidcarcinomaatypicaladenoma

2、Postgraduate:RenJunqiSupervis:Prof.NijatiRehemuAbstractObjective：ToinvestigatetheimmunohistochemicalexpressionofHBME1（humanbonemarrowendothelialcell1）、Galectin3CD44v6infollicularthyroidcarcinoma(FTC)atypicalthyroidadenom

3、a(ATA)，findingouttheusefulmarkersfitsclinicopathologicaldiagnosispartofitspathogenesis，resolvingthedilemmasininthediagnosisofthyroidfolliculartums.Methods：SPimmunohistochemicaltechniquewasappliedtodetecttheexpressionofHB

4、ME1、Galectin3CD44v6in37FTC18ATA，10oncocyticthyroidadenoma(OTA)、8generalfollicularadenoma(FTA)、7papillarthyroidcarcinoma(PTC)5nmalthyroidfromautopsyweretobeusedascontrolgroups.Results：TheexpressionofHBME1，Galectin3CD44v6w

5、ere70.3%、64.9%62.2%inFTC，were66.7%、61.1%61.1%inATA，respectively.ThesethreemarkershasnostatisticallysignificancedefferencesinFTCATA(χ2Pvaluewere0.0740.786，0.0940.759，0.2450.62，respectively).IncontrolgroupstheexpressionofH

6、BME1Galectin3CD44v6werealldletostrongpositiveincytoplasminOTA，were37.5%(3／8)、75%(6／8)50%(4／8)inFTA，were100%(7／7)、85.71%(6／7)100%(7／7)inPTCallnegativein5nmalthyroidfromautopsy.Conclusions：HBME1、Galectin3CD44v6havenosignif

7、icanceinthedifferentialdiagnosisinFTCATA，butthepositiveofthesethreemarkersinATAmaybehintmebiologicalaggressivelythreremaybecoexistsomepathogenesisprogressioninFTCATA.Thesethreemarkershadproofedtoparticipatedthepathogenes

8、isprogressioninmanytumssoiftheremeetsuchcaseswhichexpressesoneofthesethreemarkersinthyroidfolliculartumsalthoughwecannotdiagnoseascarcinomaitalsoneedtopaymeattensionfollowupclosely.Therealsoneedmestudiestothediagnosis、di