乳頭狀甲狀腺癌的環(huán)境與遺傳因素研究.pdf

1、中文摘要乳頭狀甲狀腺癌的環(huán)境與遺傳因素研究摘要為探討乳頭狀甲狀腺癌(PTC)的環(huán)境和遺傳因素，我們?cè)谏虾Ｊ羞M(jìn)行了以醫(yī)院為基礎(chǔ)的配對(duì)病例對(duì)照研究。研究結(jié)果如下:1.單因素條件Logistic回歸分析表明，經(jīng)常吃豆制品、肉類、蛋類和水果、經(jīng)常飲茶、使用電腦、使用自來水和20年前經(jīng)濟(jì)水平高是PTC的保護(hù)因素OR值分別為0.5890.4920.4180.5260.5520.7240.515和0.403甲狀腺腺瘤病史、放療史、CT檢查史、核磁共振

2、檢查史、腫瘤家族史、出生時(shí)母親年齡2、生育史、避孕藥服用史和婦科疾病史是PTC的危險(xiǎn)因素，OR值分別為2.3754.0002.2003.2503.500和2.750:初潮年齡20歲是PTC的保護(hù)因素，OR值分別為0.4300.212和0.15902.多因素條件Logistic回歸分析表明，經(jīng)常飲茶和20年前經(jīng)濟(jì)水平高是PTC的保護(hù)因素，OR值分別為0.456和0.221.CT檢查史、腫瘤家族史和出生時(shí)母親年齡二級(jí)親屬)對(duì)照組親屬的規(guī)律。

3、零截尾負(fù)二項(xiàng)分布擬合檢驗(yàn)結(jié)果顯示，PI℃病例在家系中的分布符合零截尾負(fù)二項(xiàng)分布(了=0.19P0.05).表明P7C具有家族聚集性。GreenwoodYule和HaldaneSmith出生順序分析結(jié)果均顯示PTC與出英文摘要STUDYONENVIRONMENTALANDGENETICFACTORSOFPAPILLARYTHYROIDCARCINOMAABSTRACTInordertoexploretheenvironmentalandg

4、eneticfactorsinthedevelopmentofthepapillarythyroidcarcinoma(PTC)ahospitalbasedmatchedcasecontrolstudywascarriedoutinShanghai.Theresultsareasfollows:1.Theunivariateconditionallogisticregressionanalysisshowedthateatingmore

5、beanproductsmeateggsandfruitdrinkingteamanipulatingcomputerfrequentlyusingtapwaterandpossessinghighereconomiclevel20yearsagowereprotectivefactorsofPTCwiththeoddsratios(ORs)of0.5890.4920.4180.5260.5520.7240.515and0.403res

6、pectivelythehistoryofthyroidadenomaradiotherapythehistoryofreceivingcomputertomography(CT)ormagneticresonanceimaging(MRI)diagnosisthefamilialhistoryofcancermothersage_2thehistoryofchildbearingtakingcontraceptivesandgynec

7、ologicaldiseasewereriskfactorsofPTCwiththeORsof2.3754.0002.2003.2503.500and2.750respectivelymenarcheage_20yearsoldwereprotectivefactorsofPTCwithORsof0.4300.212and0.159respectively.2.Themultivariateconditionallogisticregr

8、essionanalysisshowedthatdrinkingteafrequentlyandpossessinghighereconomiclevel20yearsagowereprotectivefactorsofPTCwithORsof0.456and0.221respectively.ThehistoryofreceivingCTdiagnosisthefamilialhistoryofcancerandmothersage2

9、2yearsoldwhensubjectwasbornwereriskfactorsofPTCwithORsof12.9357.027and3.729respectively.EatingbeanproductsfrequentlywasapotentialprotectivefactorwithORof0.351.NegativelifeeventwasapotentialriskfactorwithORof4.370.3.Themu