胃腸道癌術(shù)后患者外周血淋巴細(xì)胞P16、cyclinD1異常表達(dá)的臨床意義.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文胃腸道癌術(shù)后患者外周血淋巴細(xì)胞P16、cyclinD1異常表達(dá)的臨床意義姓名：任曉輝申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：腫瘤學(xué)指導(dǎo)教師：裴毅20090423山西醫(yī)科人學(xué)碩Ij學(xué)位論文AbstractObiective：ToanalogytheclinicalsignificanceontheexpressionofP16andcyclinD1inbloodlymphocyteinpostoperativepatientwit

2、hgastrointestinalcancerMethods：FlowcytometrywasusedtodetecttheexpressionoftheP16andcyclinD1inbloodlymphocyteinthreegroups：43healthypeoplesforcontrolgroup，52patientswhowereoperatedasgastrointestinalcanceroneyearago，weredi

3、videdintostablegroupandadvancedgroupaccordingtotheclinicaloutcomeTheexpressioninthethreegroupswasanalogybyKruskal—WallisHtestandmannwhimeyUtest；DarwtheRoccurvetodefinitethecuritalvalue，andcalculatethesensitivityandspecif

4、icityoftheP16andcyclinDlResults：TheexpressionoftheP16andcyclinDlinperipheralbloodlymphocyteweresignificantlydifferentinthethreegroups(尸005)butTheexpressionoftheP16instablegroupwashigherthanthatincontrolgroup(尸O001)Drawth

5、eRoccurvetodefinitethecriticalvalueofrecidivision：P16was671，cyclinD1was622；Thesensitivityandspecificity；P16was824％、80O％，respectivelycyclinDlwas765％、857％，respectivelyFurthermore，thesensitivityandspecificityofthecombinativ

6、edetectionofthetwoindexwas824％、943％respectivelyConclusion：ItisimportantthatThehighexpressionoftheP16andcyclinD1inbloodlymphocytetojudgeoftherecidivationandprognosisofgastrointestinalcancerKeywords：gastrointestinalcancer；