1、浙江大學碩士學位論文N正丁基苯并異噻唑酮的合成研究姓名：王凌申請學位級別：碩士專業(yè)：應用化學指導教師：胡望明20060501浙江大學磷士學位論文ABS薯RACTTransdermaIdeliverysystemisakindofdrugdeliverysystemthatdrugs，whichpenetratetheskinsabsorbedbycapillaryvesseIenterintothebodycirculationandb
2、ringIntocurativeeffect1nordertoovercometheskinbarrierpenetrationenhancersareoftenusedtoincreasetheblooddrugconcentrationsothattheskinpenetrationvelocityandconcentrationofthedrugscanreachthecurativedemandTherefore，thedeve
3、lopmentandapplicationofpenetrationenhancerbecomeextremelyimportantThisthesisjsaboutthesynthesisofanewpenetrationenhancerofgreatefficiency：thiazoneOrthogonaltestmethodwasusedforstudyingonthesynthesisofthiazoneunderphasetr
4、ansfercatalysiscondition，usingsodiumsaccharinand1butyIbromideasreactantstetrabutvIammOniumbromide(TBAB)asphasetransfercatalyst。Themainfac幻rsandtheminortactorswerediscussedthroughtheexperimentsTheexperimentaIresultsindica
5、tedthattherea&iontemperatureandthedosageof1_butylbromidewerethemainfactorswhilethereactiontimeandthedosageofTBABweretheminorfactorsTheincreaseofreactiontemperatureanddosageof1butylbromidecouldbothincreasetheyieldofproduc
6、tincertainscopebuttheexcessincreasingofthemmightbringinmuchbyproductsExtendingthereactiontimecouldnotremarkablyincreasetheyieldofproductWhenthemolarratioofTBABand1出utyIbromidewasabove005：thelncreaseofT8ABdosagecouldhardl
7、yincreasetheyieldTheoptimizedparameterswerethatthefeedingofsodiumsaccharinand1由utyIbromidewasonthetheoryratioat100℃for10hundertheconditionthatthemolarratioofTBABand1一butylbromidewas005：1Thustheyieldwas8763％withwhitedrysh
8、eetcrystalobtainedAnewsynthesistechniqueofthiazonewasdevelopedThefeedingofsodiumsaccharinand1butyIbromidewasonthetheoryratiointhesolventofOMFwithoutanyphasetransfercatalystTheexperimentalresultslndicatedthattheyieldofpro
9、ductincreasedatfirstbutdecreasedafterwardswhenincreasingthereactiontemperaturefoftheexcesslncreasingoftemperaturebroughtinthebyproductsjncreaseThemostappropriatetemperaturewas100℃ThemeltingpointdeterminationthelRspectrum
10、analysisandtheelementanalysisofthiazonewerecarriedoutTheresultsmatchtheIiteraturevaluesandthetheoryvaluesBesidesthese，theside。reactionandtheseparationofimpuritywerediscussedinthethesissupportingthefurtherresearchinthefut