19839.基于復(fù)雜網(wǎng)絡(luò)的人類(lèi)視網(wǎng)膜色素變性的位點(diǎn)基因型相互作用網(wǎng)絡(luò)構(gòu)建及相關(guān)性分析

1、分類(lèi)號(hào)：N94密級(jí)：公開(kāi)UDC：004學(xué)校代碼：11065碩士學(xué)位論文基于復(fù)雜網(wǎng)絡(luò)的人類(lèi)視網(wǎng)膜色素變性的位點(diǎn)基因型相互作用網(wǎng)絡(luò)構(gòu)建及相關(guān)性分析基于復(fù)雜網(wǎng)絡(luò)的人類(lèi)視網(wǎng)膜色素變性的位點(diǎn)基因型相互作用網(wǎng)絡(luò)構(gòu)建及相關(guān)性分析胡建龍指導(dǎo)教師邵峰晶教授學(xué)科專(zhuān)業(yè)名稱(chēng)計(jì)算機(jī)科學(xué)與技術(shù)論文答辯日期2015年6月5日AbstractTheanalysisofpathogenesisofgeicdiseasesoftenrequireslargeexpensi

2、vebiologicalexperimentslongtimeexperienceaccumulationoftheclinicaldiagnosisofgeicdisease.Thebiologicaldatawasveryhugecomplex.Therefethispaperusedataminingtechnologycomplexwktheytodesignthediscoverymethodofpathogenesisofg

3、eicdiseaseswhichmakesthediscoveryprocessautomationshtensthediscoverytimereducesexpenseshavesomereferencevaluetopredictdiagnosetheillnessinthemolecularlevel.Therefebasedonhumanretinitispigmentosacasescontroldatasetthispap

4、erusedataminingtechnologycomplexwktheytofindthepathogenicmechanismofhumanretinitispigmentosa.Themainresearcheswksofthispaperareasfollow:(1)highefficiencyminingalgithmfassociationrulesbetweenphenotypeslocus.Thispaperpropo

5、sedmatchtofindabiologystatisticalsignificanceassociationruleswithlowsupptusedparallelcomputingtospeedupassociationrulesalgithm.(2)Toconstructtheinteractionwkbetweenlocigenotypes.Thispaperuseassociationrulealgithmstofindt

6、heinteractionbetweenlocigenotypes.Thispaperconstructlocigenotypesinteractionwkwithlocigenotypesasnodesinteractionoflocigenotypesasedges.wkofcasescontrolswereconstructedthenthispapercompareanalyzethestatisticaldiscrepancy

7、ftheproptiontopologicalpropertiesofnodesbetweenthetwowks.(3)TorevealpathogenicmechanismofhumanretinitispigmentosabasedonLocigenotypesinteractionwk.Thispaperfind3nodemotifsincasescontrolslocusinteractionwkrespectivelythen