抗疏健骨顆粒對去勢大鼠骨、腎、下丘腦組織PPARγ2蛋白表達的影響.pdf

1、陜西中醫(yī)學(xué)院研究生學(xué)位論文獨創(chuàng)性與真實性聲明本人鄭重聲明：在我呈交的學(xué)位論文中，本人經(jīng)研究所得的數(shù)據(jù)、原理、結(jié)論等一切內(nèi)容均真實，且經(jīng)本人認真核對無誤：我呈交的與學(xué)位論文相關(guān)的資料(原始記錄、照片、錄像片、檢查化驗報告單等)確為完整的學(xué)位論文研究中的原始資料，本人沒作任何修改：我呈交的學(xué)位論文是我本人在指導(dǎo)教師的指導(dǎo)下進行的研究工作及取得的研九成果。除文中特別加以標注和致謝的地方外，論文中沒有其他人已經(jīng)發(fā)表或撰寫過的研究成果，其他人對我

2、完成此論文的幫助以及對本研究所做的任何貢獻均已在論文中作了明確說明并表示謝意。我呈交的學(xué)位論文及與該論文相關(guān)的資料若有不實之處，本人承擔一切相關(guān)責任。學(xué)位論文作者簽名：日期：2014關(guān)于學(xué)位論文使用授權(quán)的聲明本人完全了解陜西中醫(yī)學(xué)院有關(guān)保留使用學(xué)位論文的規(guī)定，同意學(xué)校保留或向國家有關(guān)部門機構(gòu)送交論文的印刷版和電子版，允許被查閱和借閱。本人授權(quán)陜西中醫(yī)學(xué)院可以將本學(xué)位論文的全部或部分內(nèi)容編入有關(guān)數(shù)據(jù)庫進行檢索，可以采用影印、縮印或其他復(fù)印

3、手段保存和匯編本學(xué)位論文。(保密論文在解密后應(yīng)遵守此規(guī)定)學(xué)位論文作者簽名辨位論文導(dǎo)師簽名：’日期：2014年5月浮似望AbstractPurpose：ThroughtheexperimentsinfluenceofKangshujiangugranuleonovariectomizedratsbone，kidney，hypothalamictissueperoxisomepr01iferatoractivatedreceptorgam

4、ma2proteinexpression，fromthemolecularlevelresearchthemechanismofKangshujiangugranuleeffectsonosteoporosisinpostmenopausal，forKangshujiangugranuleareusedonPostmenopausalosteoporosisprovideexperimentalevidenceofclinicaltre

5、atmentMethod：Accordingtotheweightofeach1ayerandlayer，methodofrandomization，50femaleratsweredividedintofivegroups，respectively，intoshamoperationgroup，modelgroup，osteoporosisgroup，largedoseofKangshujiangugranulemediumdoseg

6、roup，10wdoseofKangshujiangugranulegroupUseofpostmenopausalosteoporosisinratmodelof，，classicmodeofovariectomizedmodel，，，themanufacturingofpostmenopausalosteoporosis：Kangshujiangugranulehigh—dosegroup，osteoporosisgroup，mid

7、dledoseofKangshujiangugranuleinsmalldosegroupandmodelgroupratswerebilaterallyovariectomizedmodelmanufacturingmenopauseosteoporosisShamoperationgroup，ovariectomizedaroundthesamesizethegreateromentum，fordifferencesbetweent

8、hegroupsfromoperationtrauma0neweekafterestablishingthemodel，intragastricadministrationKangshujiangugranuleofhighdosegroupwasgiven2869／kgofKangshujiangugranule，osteoporosisinmiddledosegroupweregiven1439／kgofKangshujiangug

9、ranule，Kangshujiangugranule10w—dosegroupweregiven0719／kgofKangshujiangugranule，adddistilledwaterusewillbeKangshujiangugranulepreparedintodifferentdrugsconcentrationsuspensiongavage：shamoperationgroupandmodelgroupweregive

10、n2mlnormalsalineAfter12weeksTaketheleftfemuron1／3，theleftkidney，1／2hypothalamictissueAfterdrawnweresacrificedDetectbone，kidney，relativecontentofhypothalamictissuePPARY2proteinexpressionusingWesternblotratsTheresultsanaly

11、zedbySPSS17OsoftwareResuIt：Bonetissueinmodelgroup：grayvalueofgrayvalueincreasedthanshamoperationgroup(P005)wasstatisticallysignificant，Kangshujiangugranuleinthetreatmentgroupthanthoseinthemodelgroupandgrayvalueofgrayvalu

12、edecreased(P005)wasstatisticallysignificant，comparisonbetweeneachdosegroup，middledosegroupwasthelowest(P005)graySignificance：inrenaltissueofmodelgroup：grayvalueofgrayvalueincreasedthanshamoperationgroup(P005)wasstatistic

13、allysignificant，Kangshujiangugranuleinthetreatmentgroupthanthoseinthemodelgroupandgrayvalueofgrayvaluedecreased(P005)wasstatisticallysignificant，comparisonbetweeneachdosegroup，middledosegroupwasthelowest(P005)graytherewa