犬洋蔥中毒機理的研究.pdf

1、Y77486分類號密級單位代碼：10019學號：S02327嘴目巖嚏文等碩士學位論文犬洋蔥中毒機理的研究Studiesonthemechanismofonionpoisoningindogs研究生：廑掰吐指導教師：夏迷玉副熬援申請學位門類級別：盛堂亟專業(yè)名稱：監(jiān)壓獸醫(yī)堂研究方向：盞醫(yī)臨壓萱差生生壹瘤所在學院：動物醫(yī)堂暄二00五年五月AbstractSixadult，clinicallynormalPekingesewiththebody

2、weightof68kgwereutilizedbymeansofcomparingthepreexperiencetothepost—experienceinthisstudyTheywerefedcookedonionsat30∥kgbodyweightfor2daysTheparametersincludingbloodroutineexamination，liverandkedneyfunction，reticulocytean

3、dHeinzbodycount，theactivityofglucose6一phosphatedehydrogenase(G6PD)，theantioxidantsystemoferythrocyte，thefluidityoferythrocytemembraneerylbrocyledeformabilityweremeasuredprefeedonionandonday1，3，5，8，12，18，24postfeedonionTh

4、eurinewasexaminedonthenextdayofphIebotomizfngResultsareasfollows：1Bloodandurineroutineexamination：Bycomparedwithprefeedonion，theRBC，HGBandHCTdecreasedsignificantlyonday3postfeedonion(p005)；theactivityofASTincreaseddramat

5、icallyoilday3postfeedonion(p001)；thelevelsofBUNandCREfluctuatedsiginificanfly，butalsowerebetweenthenormalranges；comparedwithprefeedonionthelevelsofTotalBillandDirectBiliincreaseddramaticallyonday1post—feedonion(p‘O01)3Re

6、ticuloeyteandHeinzbedy：Comparedwithpre—feedonionthereticulocytecountincreasedsharplyoilday1postfeedonionandreachedapeakonday8(pO01)；theHeinzbodycountincreasedsignificantlyondaylpost—feedonion(p001)andgottoapeakonday34G6P

7、Dandtheantioxidantsystemoferythrocyte：TheG6PD’sactivitydecreasedonday】postfeedonion(p‘O01)anddecreasedthelowestonday5，thereweredramaticallydiferrencescomparedwithpre—feedonion；thecontentsofNADPHGSHdecreasedsignificantlyo

8、nday1postfeedonion(pO01)andthelevelsoflt102，MDAincreasedsignificantlyonday1postfeedonion(p0oi)comparedwithprefeedonion，buttheactivitiesofGHSpxandCATchangedrulelessly5Thefluidityoferythrocytemembraneandtheerythrocytedefor

9、mability：Thefluorescencepolarizationparameter(P)andthemicroviscosity(q)oftheerythrocytemembraneincreaseddramaticallyoilday1postfeedonion(p001)Theerythrocytedeformability(D1)appearedadowntrendsincefedonionThereisapositive

10、correlationbetweenMDAandprl，thecorrelationcoefficientis0908andO922respectively(p001)；thereisanegativecorrelationbetweenMDAandDIthecorrelationcoeffIcientis0887(p005)Keywords：Dogs，Onionpoisoning，G6PD，Theantioxidantsystemof