地塞米松和左旋咪唑對雞體液免疫反應的影響.pdf

1、華中農業(yè)大學碩士學位論文地塞米松和左旋咪唑對雞體液免疫反應的影響姓名：竇樹龍申請學位級別：碩士專業(yè)：基礎獸醫(yī)學指導教師：操繼躍2002.5.1TheEffectsofDexamethasoneandLevamisoleonHumoralImmuneResponseinChicksVeterinarypharmacologyGraduate：DoushulongAdvisor：CaojiyueAbstract：Dexamethasone(

2、Dex)andlevamisote(Lev)areusedonveterinayclinicfrequently，whichpossiblyinfluencethehumoralimmunityresponseofanimalsChickswereadministeredDexandLevatdifferentdosagesbydrinkingfor5daysduringthefirstinoculatingperiodandwereb

3、oosteredatpropertimeforinvestigatingtheeffectsofthedrugsonantibodyproductionBloodsampleswerecollectedat19，26，34，42，49，56daysTheNewcastledisease(ND)andtheinfectiousbursaldisease(IBD)antibodytitersweredeterminedbyhemagglut

4、inationinhibition(HI)andindirecthemagglutinationtestrespectivelyThecollecteddatawereanalyzedbyttestTheresultsindicatedthatnosignificantlylowerresponsewasmeasuredinchicksthatreceivedDexatalowdosageof05mg／L(P005)，whereasan

5、tibodytitersweresignificantlydecreasedinchicksthatreceivedthedrugeitheratamiddledosageof25mg／Loratahighdosageof75m∥L(P005)ThehumoralimmuneresponseimpairmentcausedbyDexcouldbecontroledandtheantibodytiterscouldbeadjustedto

6、controllevelorevenhigherthancontrol(P005)byusingLevatlowormiddledose，buttheimmunosuppressioninducedbyDexcouldn’tbereversedbyusingLevathighdosageof125mg／LrP005)ItcanbeconcludedthatLevisagoodimmunoaccelerantandDexshouldbeu

7、sedatproperdosagebecauseofthehumoralimmuneresponseimpairmentcausedbyitatmiddleorhighdoseThephenomenathattheimpairmentcausedbyDexcanbereversedbyLevatproperdosagelayastablefoundationforthedevelopingofnewmedicamentwithadvan