頭孢菌素C發(fā)酵液的膜過濾工藝研究.pdf

1、河北科技大學碩士學位論文頭孢菌素C發(fā)酵液的膜過濾工藝研究姓名：蓋來兵申請學位級別：碩士專業(yè)：化學工程指導教師：劉方方高春平20090601河北科技大學碩士學位論文ABSTRACTCephalosporinCistherawmaterialofcephalospronicantibioticsusedmostwidelyathomeandabroadInhighdensitysuspendingcultivation，theunusual

2、thicknessofthefermentationbrothbringsdifficultytofilterseparationFilterseparationisakindofnewtechnologywhichCallbeusedforseparation，concentration，purificationandcleanseUltrafiltrationfilterisallimportantbranchoffiltersep

3、arationtechnologywhichemployeesflmicroporousfilterandtheliquorpermeatesthefiltreunderpressuredrivingOnthebasisofthefermentationbrothsystemofmicrobe，wehadstudiedtherheologicalpropertyandthecompressibilityofthebrothandthep

4、rocessoffilterseparationofcephalosprinCfermentationbrothTheobjectmatterwasasfollows：1Throughanalysingtheassayofdensityofthebroth，anewasayhadbeenraisedWiththenewassay，thecalculationoftheyieldofmembraneseperationhasbeenrat

5、ionalandtrueThenewassaywouldbesuitablenotonlyforcephalosporinCbrothbutalsoforotherbroths2TherheologicalpropertyofthiskindofmultiphasesystemwasdevelopedinthispaperWeconfirmedtheconstitutiveequationbyCassonbodyofeephalospo

6、rinCfermentationbrothIthadbeenfoundthatthisnon—NewtonialfluidhasthixotropiccharacterThethixotropytheoryofthisnonNewtonialfuidascephalosprinCfermentationbrothWasperfectedAnewconcepthasbeenputforward，whichwasallexpressiono

7、ftimeandfavoursanalysingtherheologicalpropertyofcephalosporinCfermentationbrothAgoodmeasurethatoil—beancouldbedecreasedinthebrothmightbeappliedtoindustrialproduction3ThroughstudyingcephalosporinCbroth，weconfirmedthatceph

8、alosporinCbrothWascompressibleandthevalueofthecompressibilityofitscakerangedfromO30~o45Anewconceptoftheeffectualpressuredropoftransferringmembrane(APe)Wasraisedandwethinkedthefluxwasproportionalto△PeTheeffectofthecompres

9、sibilityonmembraneseparationstudied，wedrewtheconclusionthatthedecreaseofthecompressibilityandtheviscosityWasfavourabletoAPeandflux4Theprocessoffilterultrafiltrationstudied，weobtainedtheeffectoftimeonflux(kst)andpermeabil