順鉑聯(lián)合泰素化療對晚期卵巢癌作用的評價.pdf

1、第二軍醫(yī)大學碩士學位論文順鉑聯(lián)合泰素化療對晚期卵巢癌作用的評價姓名：楊龍濤申請學位級別：碩士專業(yè)：婦產(chǎn)科學指導教師：陳誦芬尹格平20040426TheevaluationofchemotherapybycombiningcisplatinwithTaxolinadvancedovariancancenGraduate：Long—TaoYangTutor：ProSong—FenChenProGePingYin【Abstract】Objec

2、tiveToevaluatetherapyvalueofdifferemchemotherapymethodsinadvancedovariancancerbythreekindsofbiologicalparametersandaclinicalparameterMethodFi時一eightpatientswithadvancedOVariancarcinomawhoseasciteshadbeennotobviouslydecre

3、asedbysinglecisplatinabdominalcavityaffusingchemotherapyafter23weekswereaffusedcisplatincombinedwitIlmainliningTaxolagainOvariancarcinomacells(OCC)suspensioncollectedfromascitessamplesindifferentgroupsandperiodsTheApo、CD

4、54andTrailfactorofOCCwereassayedbyflowcytometry(FCM)，asciticcontentwerechecked—upaswellResultTheApo—CD54、Trailfactorandascitescontentsbetweengroupswerenotstatisticallydifferentbeforechemotherapy(PO05、，theApoandTrailfacto

5、rbecameobviouslymoreimprovedinassociatedgroupthansingone(PO05，PO01)，TheCD54andtheasciticcontentssignificantlydecreasedtoo(P001P001)ConclusionThroughthreekindsofbiologicalparametersandaclinicalparameterthisstudysuggeststh

6、atcisplatincombinedwithTaxolchemotherapyisaneffectivemethodfortheadvancedovariancarcinomabeforeoperation，whichhaveagoodeffectforrebelliousascitesandisaperfectchemothet印yinadvanceforcongenericpatiemsandCanimproveoperation