8-氮腺苷的合成與工藝優(yōu)化.pdf

1、南京理工大學(xué)碩士學(xué)位論文8氮腺苷的合成與工藝優(yōu)化姓名：毛長龍申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：朱晨光杜楊20090525Abstract碩士論文Abstract8azaadenosineisoneoftheheterocyclicmodifiednucleosidecompounds，whichhasveryimportantphysiologicalfunctionsandobviousinhibitiontotherepli

2、cationofDNAandRNAItalsohasagoodantivirusactivityandCanbeusedincureofAIDSandcancerwhichshowsagoodmedicalprospectThereforeresearchonsynthesisandoptimizationof8azaadenosineisofgreatpracticalvalueThisdissertationdesignedseve

3、ralsyntheticmethodsAfterafilllevaluation，abestsyntheticrouteWasdeterminated，whichWasalsoverifiedbymechanismanalysisStartedfrommalononitrileandfreshdiazoniumsalt，phenylazomalononitrileWasobtained，andtheneyclizedtoobtain46

4、diamino5phenylazopyrimidinewithformamidineaceticathightemperatureAfterthereductionoftheformerproduct，itwasthendiazotizedandcyclizedand8AzaadenineWasobtainedFinally8azaadenosinewasobtainedafterthereactionwithtetraacetater

5、ibofuranoseThissyntheticrouteWasquitefeasiblebecauseofcommonrawmaterialsandmildreactionconditions，besides，eachintermediatewassolidandwasconvenienttopurlfledanddealtwithwhichsatisfiedtheindustrializationrequirementsSingle

6、factorexperimentswerecarriedtodeterminethemosteffectiveconditionssuchasreactiontime，temperature，materialratioandcatalyzerdoseSeveralsyntheticmethodswerecarriedouttodeterminesche：ruesthatmeetdifferentrequirmentsEachinterm

7、ediatewascharacterizedbythemeltingpointdetermination，infraredspectroscopy(IR)，mass(MS)，1Hnuclearmagneticresonance(HNMR)，theresultsshowedthattheyareinlinewiththetargetproductsTherourteofsynthesisof8azaadenosineWasverified