扁平苔蘚皮損中VEGF、p-Akt、Survivin表達與凋亡的關(guān)系.pdf

1、山西醫(yī)科大學碩士學位論文扁平苔蘚皮損中VEGF、pAkt、Survivin表達與凋亡的關(guān)系姓名：馮珺申請學位級別：碩士專業(yè)：皮膚病與性病學指導教師：白莉20100517山西醫(yī)科大學碩士學位論文StudyontheexpressionofVEGF、pAktandSurViVinandcenapoptosisinIichenplanusAbstractObjec晰e：T0姍舊stigatct11eexpresSionofⅥ三GF、p礎(chǔ)t鋤d

2、Sun，ivin舯otei璐鋤dt|把levelofapoptosisofkcratiIlocytcsA枷y∞meroleofP13臥msignalp礎(chǔ)wayill齜pa置：hogenesisofli‘jhenplarmsMethods：I加munohi咖ch鋤icaltccllIliquew鶴employedt0studymeexpressionofVEGF、pAⅪ鋤dSurvivinin30c邪esoflichcnplaIlus鋤d

3、30c嬲esofnomlalsl【in1UNELw觴uSedt0smdyⅡleapoptosisofkeratinocytcsTherclatio璐llipaInong吐leexpressionofVEGF、pAkt趾dSurviVinw嬲雒alyzedR懿ults：1kpositiVeexpressionofVEGF、pAI(t鋤dSl】rmillShowsyellow0rbrowIl孕amdesint：hccytopl弱m，theI

4、OD(inte黟atedopticalde腦it功Valuestonles呦gmof也epositiveeX講essionCompa他d誦tlln倫nonnalgroup，Ⅱ圮IOD0fVEGF、pAktandSurviVinwe塢13584113l、144051263andlO5371212wllichwe犯uprejgulatedinlich髓plam塔speciellS(PO01)，鋤dtherew勰si91lific觚tlypo

5、sitiVecorrelationbetw∞ntheeXpressionofVEGFandS1刪啊n，VEGF鋤dp礎(chǔ)t，pAkt鋤dSurvivinilllesionalepidennis(PO01)Theker撕noytesm、V嬲728179234illlichenpI鋤瑚，、)ldlichw嬲si嘶fic鋤tlyhighertllaIlits281603464innomal幽n(尸001)Conclusion：Theexprcs

6、sionofsⅢviViIlgcanbepromotedbythe11ighleVelexpressionofVEGFviaP13l|∽心si掣1alpa幽wayinlichenplalluSThepanlogeneSisofLichenplanlISmaybe嬲sociated塒tlltheP13l；∽kl【tsigI礎(chǔ)p甜1way11leh)，pellprolifer：ation柚doverapoptosisof㈣iIloc”esm