腎細(xì)胞癌血管內(nèi)皮生長(zhǎng)因子和血管生成的研究及意義.pdf

1、同濟(jì)醫(yī)科大學(xué)碩士學(xué)位論文腎細(xì)胞癌血管內(nèi)皮生長(zhǎng)因子和血管生成的研究及意義姓名：丁樹平申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：泌尿外科指導(dǎo)教師：周四維曾進(jìn)19990501TheStudyandClinicalsignificanceofVascularEndothelialGrowthFactorandAngiogenesisinHumanRenaleellCarcinomaDepartmentofUrology，TongjiHospital，Tongji

2、MedicalUniversity，HubeiChina430030DingShupingZengJinZhouSiweiAbstractObjectiveTostudyandanallyzetherelationshiPhetweenvascuJHrendothelialgrowthfactor(VEG[)andangiogenesisaswel1asclinicopathologicfactotsandpt’ognosisinhum

3、antealcellCaFCinomft(ICC)toprobethefeasibijitYofbackgroun(factorsasaproguosticindicatorfor’patieetswithRCCMethodsVEGFpt’oteinexpi’essinllandmicrovesselCOUrtts(IIVC)ofparaffjnembeddedspecimensIrom66easesl／CCwhoha(】undel’g

4、oneradiCalnephrectomywereexgriiJnedbvimmurlohist0109iC￡t1SLainingVli(；IDositiv【IyHtainedcancercellspe]’t00andHIicrovessselsper200XweleCeHUtc(JwiLh1ightmicroscoperespecLivelYVI吲expt’essionandMVCwellel『1【【yzedtogetherwitit

5、heir1clnLiontosexandage、caneel’celltYpe、nucleal、Ejade、tumofsrage、riletastassaswel【aspE’ognossResultslhemein州CwasSigniC；tt／L1YhigheriaturiiofsLlatexpllesscdiigb(III)VEGI】evelsLhaninthosethatexpressed10W(I)VE(；F1evels(P(00

6、1)VEG]andMVCposnivelYcorrelaLedwithtumorCeilnucleargrade、tumorstageandmetastasis(P0，05)，The5yearsurvivalraLewassignificantlY10werinICCpatientswithstron91YpositiveexpressionofVEGF(IIIII)orwiLhIIVC≥102(PO05f’O01)Theprobabj

7、lityofovcr5YearsurvivaIratewasestimatedbyp=e∽mH’湖”州6”刈‘圳”。／(1e==m‘1j‘’86‘Ⅵ‘’”一‘I”“：’’、lVC)(PO01)MultivariatcanalysisindicatedthatbethVEGFandIIVCare3nindependentvaluefactotaffectingprognosisinRCCbutprognosticvalueofMVCaff

8、ectingRCCOUtcomeissuperiortoVEGF一ConclusionVEGFiscloselyrelatedtoangiogenesisofRCCandpromotesgrowth、invasionandmetastasisofRCCHighVEGFexpressionand^ⅣCMaybeunfavorableprognosticfactotforpatientswithRCC，theyareusedtodiscri

9、minatepatientsofhighriskmetastasisandpoorprognosisTherefore，weinvestigateVEGFhowtoinducetumorangiogenesisanditsmechanismthefuturedevelopmentofangiogenicinhibitorsandsuppresionofangiogenesisaswellasprogressioninRCCWillbe1