胸腺瘤病理學(xué)和伴胸腺瘤重癥肌無力臨床診治的研究.pdf

1、第二軍醫(yī)大學(xué)博士學(xué)位論文胸腺瘤病理學(xué)和伴胸腺瘤重癥肌無力臨床診治的研究姓名：吳濤申請學(xué)位級別：博士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：丁素菊涂來慧20040301Thepathologicalclassificationsofthymomasandtheirclinicalrelationshipwithmyastheniagravisandclinicalfeatures[Abstract]ObjectiveTostudytheWHOclassi

2、ficationandtraditionalclassificationofthymomasandevaluatetheirclinicalValUeSMaterialsNinetyfivecasesofthymomaswerestudiedbytraditionalclassificationandtheclassificationproposedbytheWorldHealthOrganization(WHO)ThereLation

3、shipsbetweenthesubtypesandmyatheniagravis，invasivenessandprognosiswereanalyzedResultsIntraditionalclassification，therewere19casesofpredominantlyepithelialthymoma，42casesofpredominantlylymphocyticthymoma22casesofmixedtype

4、，7casesofspindlecelltypeand5casesofthymiccarcinomaThespindlecelltypewaslessinvasiveandaccompaniedwi也lessMGThepredominantlyepithelialthymomasweremoreinvasivethanpredominantlylymphocyticthymomas(PO05)InWHOclassification，th

5、erewere7casesoftypeA，16casesoftypeAB，33casesoftypeB1，24casesoftypeB2，10casesoftypeB3and5casesoftypeCMyastheniagravisWasassociatedin167％、50％、714％、917％、667％andO％inpatientswithtypeA，AB，B1，B2，B3andCthymomas，respectivelyInvas

6、ivetumorswereseenin167％、313％、314％、708％、100％and100％oftypeA，AB，B1，B2，B3andCthymomas，respectivelyThesurvivalrateatfiveyearsofAandABtypesWas917％Btypes731％(B1846％，B2625％，B360％)andCtype333％respectivelyThesurvivalratesweresigni

7、ficantlyhigherforpatientswithAandABtypesofthymomasthanpatients、vitllBandCtypesofthymOmasfP005andP001)ConclusionTheBtypesofthymomasinWHOclassificationweremoreinvasiveandassociatedwithmyastheniagravisandhadpoorprognosis，wh

8、ereastheAtypewaslessassociatedwithmyastheniagravisandhadbetterprognosisTheWHOclassificationofthyrnomaswascloselyrelatedtoaccompanywithmyastheniagravisandreflectedtheclinicalfeaturesandthefunctionsofthymicepithelialtumors