LDL-吸附劑的優(yōu)化選擇與高脂血癥血液灌流治療的動物實驗研究.pdf

1、天津醫(yī)科大學碩士學位論文LDL吸附劑的優(yōu)化選擇與高脂血癥血液灌流治療的動物實驗研究姓名：崔韜申請學位級別：碩士專業(yè)：神經病學指導教師：程焱2002.5.1天津醫(yī)科大學碩士學位論文AbstractTheassociationbetweenhyperlipidemiaandatherosclerosisisunequivocalAndlowdensitylipoprotein(LDL)subclassesdifferconcerningth

2、eiratherogenicpotentialSmall，denseLDLaremoreatherogenicthanlarge，buoyantLDLLDLapheresisisabettertreatmentoptionforpatientswithrefractoryhyperlipidemia(especiallyfamilialhypercholesterolemia)whofalltespondadequatelytodiet

3、anddrugtherapyInordertodevelopabetteradsorbent，wehavedesignedseveraldifferenttypeofadsorbent(dextransulfateadsorbent，dextranadsorbentwithamphiphilictigandsandcelluloseadsorbentwithamphiphilicligands)Alloftheadsorbentwere

4、comparedconcerningtheirefficacybymixedplasmainvitroTheresultshowscelluloseadsorbentwithamphiphilicligandsispreferabletoothers(JD005)AndLDL，TC，TGwereselectivelyremoved儼001)withoutthesubstantialreductionofhighdensitylipopr

5、oteinTheeffectsofcelluloseadsorbentwithamphiphilicligandsonplasmalipidofrabbitwithhyperlipidemiawereobservedThesorbentremovedTC，TGandLDL(PO01)，leavingHDLintactAndonthebasisof3LDLsubfractions(d=1020一l060∥m1)isolatedbydens

6、itygradientultracentrifugationtheLDLdensityprofilewasdeterminedineachrabbitwithhyperlipidemiabeforeandaf=erapheresisAlloftheLDLsubclasseswerereducedButtherewasarelativeincreaseofLDL—subfractionland2andaconcomitantdecreas

7、eofLDLsubfraction3afterperfusionTheextentofsmall，denseLDLreductioncorrelatedwiththepreapheresisconcentrationofLDLbutnotwiththatoftirglycerideThephysicalorchemicalcharacterofsLDLmaybecontributetotheresultthatthedegreeofsm