全血灌流重癥肌無力免疫吸附劑血液相容性實驗研究.pdf

1、延邊大學(xué)碩士學(xué)位論文全血灌流重癥肌無力免疫吸附劑血液相容性實驗研究姓名：李英信申請學(xué)位級別：碩士專業(yè)：生理學(xué)指導(dǎo)教師：孟繁平20070520i咝叁蘭竺些蘭主些竺!：竺絲堡苧AbstractBloodcompatibilitystudyofimmunoadsorbentinmyastheniagraVisbywholebIoodperfhsionAbstractobjective：Tbprepareaspecificimmunoadsor

2、bentforpathogenic’Ketylcholinereceptorantibodies(AChRAb)inmyaStheniagravis(MG)TheadsorptiVemech鋤ism柚dbIoodcompatibilitycharacterofadSorb鋤twercstIldiedbywholebloodpedhsionexperimentMethods：11leceIlulOsebeadswercprepared鷦c

3、枷ersA10synthesizedaminoacidsofmainimmunogenicregionofhum鋤AChRorL—tryptoph鋤，aslig卸dswereimmobilizedoncellulosebeadstomakeimmunoadsorbentsrespectiVely1nthisexperimentthenomlal12rabbits、veremndomlydividedintothreegroups，idc

4、ludingcontrolgroup(grolJpA，onlycellulosebeads)，L蚵ptophallgroup(groupB)aIldspecificgroup(gmupC)Bloodcells，ions柚dplasmaproteins、vereexaminedbefore加daRerexperiment，testwaS印pliedina11alysisofthedataResults：ThereⅥrasnosignifi

5、caIItdi婦’erellceingroupAinbloodcens，ionsandproteinsbefbre鋤da舭rexperimentTherewerenonsignificalltdi虢rencesbetweengroupBandgroupCinbloodcellsandinions，butitⅥ，assignificantdecreasedinpIaSmapmteinsingroupB卸dingroupCPlasmatot

6、alpmteins(TP)were6050768and51OO942(PO05)，Pl∞maglobulins(Glo)were2425457柚d1950640(PO05)alldplasmaalbumin(Alb)were3625330and13150370(PO05)respectivelyingroupBTPwere5750252and4650332(，O05)，Glowere2375189鋤d1675236(P005)andAl