TGFβRII和Smad4在血管瘤組織中的表達.pdf

1、中南大學(xué)碩士學(xué)位論文TGFβRII和Smad4在血管瘤組織中的表達姓名：熊建明申請學(xué)位級別：碩士專業(yè)：外科學(xué)（普外科）指導(dǎo)教師：黃建華20050501碩士學(xué)位論文英文摘要ABSTRACTobiectiveThestudyisaimedtoinvestigatetheexpressionandsignificanceofTGFBRIIandSmad4inthehemangiomasandcapillarymalformationTheau

2、theralsosearchforthepossibletreatmentofhemangiomaMethodsTwentyspecimenswhichcamefromXiangyahospitalwereexaminedintheexpressionofTGFBRIIandSmad4inthehemangiomasandcapillarymalformationbySABCimmunohistochemistryEachsection

3、wereobservedfiveHPandcountingposffivecellsratein500，accordingposkiveceilsratewedividedthemintofourgradesResultsTheexpressionofTGFBRIIandSmad4inhemangiomawasdetectedin13／14(929％)and12／14(857％)respectivelywhichwassignifica

4、ntlyhigherthancapillarymalformation0001)TheexpressionofTGFBRIIandSmad4inhemangiomawasbothpositivein12casesandnegativein1case，apositivecorrelationbetweenthemwasobserved(r=0789)ThepositivecellsrateofTGFBRIIandSmad4was(8001

5、3O)％and(733140)％in6involutingphaseofhemangiomasrespectivelywhichwassignificantlyhigherthanproliferatingphaseofhemangiomas0O01)ConclusionsTheexpressionofTGF13RIIandSmad4inhemangiomawassignificantlyhi曲thancapillarymalforma

6、tion，especiallyininvolutingphaseofhemangiomawhichhaveapositivecorrelationThissuggestedthattheexpressionofTGFBRⅡandSmad4wascloselycorrelated謝mhemangiomaSowesuspectthatTGFBSignalinducedregressionofhemangiomasbysignalingpat