胎盤(pán)鐵蛋白結(jié)合的淋巴細(xì)胞檢測(cè)在早期乳腺癌診斷中的意義.pdf

1、復(fù)旦大學(xué)碩士學(xué)位論文胎盤(pán)鐵蛋白結(jié)合的淋巴細(xì)胞檢測(cè)在早期乳腺癌診斷中的意義姓名：朱瑋申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：外科學(xué)指導(dǎo)教師：秦新裕陳君雪2002.5.10論文ABSTRACTPURPOSEToevaluatetheusefulnessofFBL(FerritinBearingLymphocytes)inthepefiphemlbloodfordetectionofearlybreastcarlcerandtofindouttherelat

2、ionshipbetweenFBLanddifferentclinicalorpathologicalfeaturesMATERIALSANDMETHODS167femalepatients、析msuspiciousfindingsinbreastwhounderwentoperationenteredthistrialByuseofflowcytometry，thelevelofFBLintheperipheralbloodofpat

3、ientsWaSdeterminedbeforeoperationIntermsofpathologythepatientsweredividedintotwogroups，onegroupisbreastcancers，theotherisbenigndiseasesInaddition，62healthyblooddonorsservedascontrolsRESULTSValuesofFBLinbreastcancerpatien

4、tsdifferedsignificantlyfromthosefoundinwomenwithbenigndiseasesandhealthycontrols(982％VS251％and204％，respectively)AndthereWaSnodifferencebetweenbcni印diseasesandhealthycontrols(p=008)Amongthepatientswithbenigndiseases，F(xiàn)BLin

5、dysplasiapatientsdifferedfromthosefoundinpatientswithlobularhyperplasia(565％VS216％：p=0002)FBLinthepatientswithbreastcancerofstage0，IandIIdifferedfromthosefoundinstageIIIandIV(1013％VS245％p=001)Patients、vi廿lnegativelymphno

6、desdifferedsignificantlyfromnode—positivepatients(1258％VS643％；p=o002)，whereasnodifferenceasrelatedtotumorsize，menopausalandestrogenorprogestogenreceptorstatuswasobservedFBLindifferenthistologicgradingfromgradeItogradeIII

7、showedadeclinedtendency(1427％VS1084％and349％；p=0023)IntermsofRoecalve，weselect489％asthecutoffpointThesentivityofFBLfordetectionofbreastCanCerWas7941％andthespecificityWaS8788％Atthislevel，86％(43／50)ofcancerpatientswithstage

8、0andI，80％(36／45)ofstageIIandonly2857％(2／7)ofstageHIandIVwereidentifiedCONCLUSIONFBLishighlysensitiveforearlybreastcancerItCanbeusedasanassistantmethodindetectingearlybreastcancercombined、Ⅳithmammographyultrasoundandinfra