過敏性紫癜急性期血漿可溶性細胞間粘附分子-1和血管內(nèi)皮生長因子水平的變化及意義探討.pdf

1、青島大學碩士學位論文過敏性紫癜急性期血漿可溶性細胞間粘附分子1和血管內(nèi)皮生長因子水平的變化及意義探討姓名：劉偉申請學位級別：碩士專業(yè)：兒科學指導教師：張秋業(yè)2003.3.30英文摘要THESTUDYoFTHESIGNIFICANCEOFPLASMASOUBLEINTERCELLULARADHE—SIONMOLECULE一1ANDVASCULARENDO—THELIALGROWTHFACTORINPATIENTSWITHHENOCH—SC

2、HOENLEINPURPURAABSTRACTobjectiveToinvestigatethechangesandclinicalsignificancesofsoubleintercellularadhesionmolecule1(siCAM一1)andvascularendothelialgrowthfactor(VEGF)inchildrenwithHenochSchoenleinpurpura(HSP)MethodsPlasm

3、asiCAM一1andVEGFweredetectedin38childrenwithHSPinacutephaseand16normalchildrenbyELISAThelevelsofplasmasICAM一1andVEGFindif—ferentclinicalcategoriesofHSPwerecomparedResults①PlasmasICAM1levelsinchildrenwithHSPinacutephase[(3

4、672土611)ng／m1]weresignificantlyhigherthanthoseinhealthycontrols[(2591士371)ng／mOO=657，P005)②PlasmaVEGFlevelsinchildrenwithHSPduringtheacutephase[(2027112618)pg／m1]weremarkedlyhigherthanthoseinhealthycontrols[(498612421)pg

5、／m1]，(t一4783，P005)；plasmaVEGFlevelsinpatientswithgastrointestinalsys—teminvolvementofacutephase[(28006士16149)pg／m1]weremarkedlyhigherthanthosewithoutgastrointestinalsysteminvolvement[(1528814643)pg／m1]0=279，P005)；③Plasma

6、slCAM一1levelsofacutephaseofHSPweresignificantlypositivecorrela—tedtoplasmaofVEGFlevels(r=0484，P001)ConclusionsPlasmasICAM一1andVEGFinacutephaseofHSPweresignificantlyin—creased，andtheywerepositivecorrelatedtoeachother，whic

7、hsuggestthatsICAM一1andVEGFmayplayacrucialroleinpathogenesisofHSPsiCAM一1mayhaveanimportanteffetonchangesofnephritisofHSP。meanwhileVEGFmayhaveacloserealationshipwithgastrointestinalsysteminvolvementofHSPKEYWORDS：purpura，Sc