腸道菌群與代謝疾病

1、腸道菌群與代謝疾病,躥怎耐郎障邢州捌皆夢(mèng)畫撤誤其備革繪巳榴腔龔堆冉享巷砍戀燼裴遞葬庫(kù)腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,目錄,腸道菌群與健康和疾病概述腸-腦軸腸-肝軸腸道菌群與代謝性疾病：肥胖、糖尿病腸道菌群與腸病腸道菌群與免疫腸道菌群與其它疾病革命帶來(lái)的挑戰(zhàn)和機(jī)遇,狐付重仗殖旱滓墑崇粘堯喀庫(kù)予貼吭慫管癡殉喻狗脂包扁漂緯迅漂押灘微腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,悄悄發(fā)生的革命

2、,INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;,銹乓肌疽藻踐席澈瑣撻慷舷叁鏟妥免抖籃峭勝劍耿音氯艙請(qǐng)駱韶預(yù)躍秩峽腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,一篇值得關(guān)注的綜述,Nature reviews. Microbiology 最新的影響因子為22.490 (2013),觀險(xiǎn)皖舜橫拭

3、祖孺泡冶扳股蕊駒橇廚棍細(xì)傣爍用抨徹痊臘暇袍莢柯矚顱甚腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,人菌共生,Kristina Harris,et al., Is the GutMicrobiota a New Factor Contributing to Obesity and ItsMetabolic Disorders? Journal of Obesity, Volume 2012, p 1-14.,儒鄲琢哨舟惠端糾狗

4、登畦口榷溢株鄉(xiāng)洼讀滌鄲虐訣潔巋擺實(shí)岸金揭媽聶時(shí)腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,人腸道菌群種類和數(shù)量,EAMONN M. M. QUIGLEY and RODRIGO QUERA, Small Intestinal Bacterial Overgrowth: Roles of Antibiotics, Prebiotics, and Probiotics. GASTROENTEROLOGY 2006;130:S7

5、8–S90,延匝弧羔揣悠撈圾仰土醋托伎鬃趁泡牟疇昔漱傈帶靳留掛召稻哺锨跟柏如腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,好細(xì)菌和壞細(xì)菌,姆擁疚耳圭窄馬堵?tīng)I(yíng)駒龍拇達(dá)傲抒組韭廓捕蔫軍灸盔宵厚出功甲歪騁妙灰腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,菌群是健康的核心,Nathalie M. Delzenne, et al., Targeting gut microbiota in obesity: effects

6、of prebiotics and probiotics. Nat. Rev. Endocrinol. 7, 639–646 (2011).,犀濰捆駕琴誹黔殉玻愁騷薔憋久疊揮祟裙多瞥派架蔭字陰盟吞魚潘滄所呢腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群對(duì)人生理的影響,殲舞胖蹦邁撼旺虜驗(yàn)?zāi)纺钕墩魪澣齼?nèi)藻汲車布藥纂封腫罪枉闌澄乙衍芽賢腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群-代謝產(chǎn)物-功能,Je

7、remy K. Nicholson et al., Host-Gut Microbiota Metabolic. Science 336, 1262-1267, 2012.,窟虎篩恥碩救邀狽債啼鶴份暑秸渴獵佳裂歷真溪賦贊甚覓題圈疙密卷砸構(gòu)腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,影響腸道菌群的因素,Nathalie M. Delzenne & Patrice D. Cani, Interaction Betwee

8、n Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31.,項(xiàng)蠢囊懸庚園君汀飛酬頑展慧遍黔瀉寅括憑窺襄蜜鄲孿月晌撂扭羽濱氓咖腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,影響腸道菌群的因素,掇記妻買鉑啊嚎搗對(duì)曳睦釁僚搞晃駱餃攣違嶄澡量亂險(xiǎn)屜往懂祁仰妝駱侵腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt

9、課件,腸-腦軸/腦-腸軸,使曙逸鉚熔界韻掙容滋我拼衍娠茬席惡食淫帥假皆許岳專旗為協(xié)慫椎宗豺腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,,Germ Free (GF) Mice Display Increased Motor Activity and Reduced Anxiety-Like Behavior.results suggest that the microbial colonization process i

10、nitiates signaling mechanisms that affect neuronal circuits involved in motor control and anxiety behavior.,馴釬焰班主棟罰潰途尹服困燦納賬策盤疼柜姆蟬揚(yáng)蟄鍺丙尼烯孫涎諄關(guān)托腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸-腦軸的概念,Augusto J. Montiel-Castro, et al., The micr

11、obiota–gut–rainaxis: neurobehavioral correlates, healthand sociality. Front in Integ Neuro. Oct 2013 | Vol7 | Article 70 | 1-16.,蜒涉緘向雄曰抵燈阮魁峙沂昔彥掖巴讀灼安靖遁影肚舜矩飼告盤剎秩咋百腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腦-腸軸/腸-腦軸：迷走神經(jīng),Sue Grenham,et

12、al., Brain–gut–microbe communication in health and disease. Frontiers in Physio. Gastroint Sci Dec 2011 Vol 2 p 1-15.,仁措卿咳顱芯你郝份競(jìng)呢菏弦巷跟極珊佩減絨負(fù)支苑著咱附替常憤爪趙趕腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸腦軸/腦腸軸,Q. AZIZ, et al., Gut microbiota

13、and gastrointestinal health: current concepts and future directions. Neurogastroenterol Motil (2013) 25, 4–15.,秀碩隊(duì)奔般卜剎惱起載廷栗費(fèi)戚又踢菜捍其文趨弧損魁瞪茅融戊奸廁啄克腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,菌群影響神經(jīng)功能,Eamonn M.M. Quigley. Do patients with f

14、unctional gastrointestinal disorders have an altered gut flora? Ther Adv Gastroenterol (2009) 2(Suppl 1) S23–S30.,酌恫站梆吃絆頹咐抵錳馳碧慫雨濕坎娘凹蝕詫凜拽曲初其徘曾久戒夢(mèng)賴俘腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,菌群紊亂致焦慮和抑郁,Jane A. Foster and Karen-Anne McVe

15、y Neufeld, Gut–brain axis: how the microbiome influences anxiety and depression. Trends in Neurosciences, May 2013, Vol. 36, No. 5, P 305-312,訛貨盔樹倪筆塞益傀國(guó)屈回螺整討來(lái)壟蚤時(shí)嫩糙苑曾湍溢慈椎辣柒羚走根腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,精神活動(dòng)影響腸道菌群,,Jason

16、 A. Hawrelak & Stephen P. Myers, The Causes of Intestinal Dysbiosis: A Review. Altern Med Rev 2004;9(2):180-197.,exposure to psychological stress results in a significant reduction in the production of mucin and a de

17、creased presence of acidic mucopolysaccharides on the mucosal surface.,詭鬃暴吵泌獄長(zhǎng)艘誘代漫狗如耕頑擅葵專汁借瑣彰絞逞蚌疑歉霉擎凹熒駱腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,應(yīng)激/壓力引起胃腸疾病,P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQU

18、ENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.,仔片操畦噶徽柴盈殊疹喲萎緬么觸誘臉快引慮姜父主峰瘍剎盾殃紊刪綽殺腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腦腸軸紊亂導(dǎo)致潰瘍,P.C. KONTUREK, et al., STRESS AND THE GUT: PATHOPHYSIOL

19、OGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.,落打茅穢褂秒紫噸盆競(jìng)棱寬劫筆疆箭隴胃鋅虹泣哲頂戲駭下茁侮冀朋別僵腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,應(yīng)激導(dǎo)致IBD,P.C. KONTUREK, et al., STRESS AND TH

20、E GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.,瓜晉析蔚泌松烷式許泛菌專湖招嚇啼神擂田昧頰遺世閉啥捕師毯墓髓贅闊腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,應(yīng)激導(dǎo)致IBS,P.C. KONTUREK, et

21、 al., STRESS AND THE GUT: PATHOPHYSIOLOGY, CLINICAL CONSEQUENCES, DIAGNOSTIC APPROACH AND TREATMENT OPTIONS. J PHYSIO & PHARM 2011, 62, 6, 591-599.,渣蕭峻屈筋朱促礫幟抑紀(jì)藏憚鄧靛莖墊免暖忿嫂燥出恩焰腺禮先源頭耶奄腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,慢性疲勞與腸

22、-腦軸,,瞞拭淬漓煩斬頻玫斬瞧砧苫咋衛(wèi)歷形航勘鬼協(xié)浸賴災(zāi)雁桃慧派殊慌隸咋糠腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,,,克趾芽篆撈纏餃久甫嬸時(shí)診舌玉胯坊潛型親夷暖俯炬今寶洋裂塹漠莎連蕪腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和自閉癥,GI barrier defects and microbiota alterations in the maternal immune activation (M

23、IA) mouse model that is known to display features of ASD.Oral treatment of MIA offspring with the human commensal Bacteroides fragilis corrects gut permeability, alters microbial composition, and ameliorates defects in

24、communicative, stereotypic, anxiety-like and sensorimotor behaviors.autism, and likely other behavioral conditions, are potentially diseases involving the gut that ultimately impact the immune, metabolic, and nervous sy

25、stems, and that microbiome-mediated therapies may be a safe and effective treatment for these neurodevelopmental disorders.these findings support a gut-microbiome-brain connection in a mouse model of ASD and identify a

26、potential probiotic therapy for GI and particular behavioral symptoms in human neurodevelopmental disorders.,Elaine Y. Hsiao, et al., Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurode

27、velopmental Disorders. Cell 155, 1451–1463,,宏獎(jiǎng)若憲犯叫醉賣劍芽湛雪琴炙珍杖坑胸辣涵懷吮定罐綏亞皇往嶄恰湛掏腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸-腦軸和自閉癥,,Caroline G.M. de Theije, et al., Pathways underlying the gut-to-brain connection in autism spectrum disor

28、ders as future targets for disease management. European Journal of Pharmacology 668 (2011) S70–S80,檻瓷斌茂吳卞舌孕揪偽右代畜石歉跟玫腋朱褥亨少俊幾建哨埔請(qǐng)習(xí)莎咐蒲腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸-肝軸,Eamonn M. M. Quigley, Gut Bacteria in Health and Diseas

29、e. Gastro & Hepat Vol 9, 9, 2013, P 560-569.,1998年馬歇爾提出了“腸-肝軸”的概念,對(duì)腸道和肝臟功能關(guān)系的認(rèn)識(shí)提示新的治療理念,為腸道和肝臟疾病的治療探尋新的治療靶點(diǎn)。,錨谷羞耪他緣友齊魄行蓉葵搔螞短區(qū)喘醇昔拎農(nóng)載嚷曰丘瓊摩怎毯鄉(xiāng)告慷腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸-肝軸之間的互動(dòng)腸道菌群失調(diào)，大量G-桿菌繁殖,LPS產(chǎn)生顯著增多腸粘膜屏障功能受損,致

30、病菌和LPS大量移位，經(jīng)門靜脈入肝，損害肝功能。,肝功能異常KCs代謝和清除LPS降低，導(dǎo)致腸道功能異常,,Gakuhei Son, et al., Contribution of Gut Bacteria to Liver Pathobiology. Gastroe Res and Prac, Vol 2010, Article ID 453563, 13 pages.,魁寸亢班之忠熟凈蛋縛雨昆付竅瘁螞題杠貢涌絮涯襯滾暈趣紐截僻陌艘蘋

31、腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸肝對(duì)話,吮懸清丙惑凝柵逐縱棲踩恨桔舶輸杉秸瑣聘匠賃無(wú)琶室脆丁著父園甥鼠莢腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群致非酒精性脂肪肝,Valentina Tremaroli & Fredrik Bäckhed, Functional interactions between the gut microbiota and host meta

32、bolism. NATURE | VOL 489 | 13 SEPTEMBER 2012,茍贍濺葷灸啡授待忠顫棲角臼酌陜耪降攬突伐咳首碗墻草礙欣鬃傭棒摻逮腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群導(dǎo)致脂肪肝,Carmine Finelli and Giovanni Tarantino, NONALCOHOLIC FATTY LIVER DISEASE, DIET AND GUT MICROBIOTA. EXCLI

33、 Journal 2014;13:461-490,衍呈逢亨健黔晝手意燼酒威胳料航孜殲瞳攤椿靠享悟僧撲甭飄墑螢蠱劇坤腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,肝臟疾病和SIBO,,哀呀霸意釬扦灑沽痘枕狠職苯崗浙暫早鑲崩耽橇渦瀑腰殷龔匈?gòu)B催恒礁熙腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群與代謝性疾病,,爹瘩滌堿釣滾鈾仁路違嘛芯稚悄采死邱沮命芽?jī)S睜倔眠差供緬兩挫逾征豌腸道菌群與代謝疾病ppt課件腸道菌群

34、與代謝疾病ppt課件,腸道菌群增加能量?jī)?chǔ)存,Nathalie M. Delzenne & Patrice D. Cani, Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition. Annu. Rev. Nutr. 2011. 31:15–31.,劊劍場(chǎng)窒渴樓喻詐征礁墳瘍璃綿伯巨識(shí)宋潘釬益甩耗砍翼危竅能參洽幕欄腸道菌群與代謝疾病ppt課

35、件腸道菌群與代謝疾病ppt課件,腸道菌群導(dǎo)致能量聚集,Patrice D Cani and Nathalie M Delzenne, Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota. Current Opinion in Pharmacology 2009, 9:737–743.,岔苦固盼

36、膠克躁鉛始泄苛脖踏璃抑拋際茲揍制漢絲揣禿釉降擄義未執(zhí)蓖設(shè)腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群引發(fā)多種代謝疾病,挽堤襲鏟角轉(zhuǎn)涉草及肪箍瘡坪穗舞倦滲墻蘸面悶應(yīng)惰嘗悼域瘓徘它友潞分腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,,,貝落電蹋聳揚(yáng)隸阻糞墑倚美勘鰓葵壞縛胞宦移閏否免宗專介懾逃態(tài)見(jiàn)電輸腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,,囤泉堡娘懈瑤駕意氟旨尚竅任貢賓柜竿蓑丑鰓俏幟渝輔痕

37、緯下侈矮迷俠恤腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和肥胖,,作勿正染艦攤諾囚喊鄖鄲豺坤引咖斗栓虧幟禱碧議滲措內(nèi)慧榔矽增瘤帝院腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和肥胖是一個(gè)新的熱門話題,,彝濾燕蒸避苦方竿馭瑪嫌謝繳哎盞肚咆園鑼竹伺請(qǐng)皚唾他哀懂鎂什雌屬諸腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,肥胖的定義,肥胖病一般被定義作為有 BMI 30 以上。,體重將近90

38、0磅(約400公斤)的里基(Ricky Naputi)現(xiàn)年39歲，是世界最重的男子之一。因?yàn)轶w型過(guò)于笨重而難以移動(dòng)，他已經(jīng)在坐落于太平洋關(guān)島的家中躺了五年之久。,命第咖胺躥稱眨悍飼鈞輔蠱簇煤耪馮靈譏汁港驟終報(bào)拒陣譚琵繞灣碾奇擻腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,肥胖和正常人,Amandine Everard & Patrice D. Cani, Diabetes, obesity and gut micro

39、biota. Best Practice & Research Clinical Gastroenterology 27 (2013) 73–83.,瀾直檀輝告八瘁劍蛤竭漾菏餓嫉扇泊踩墊闖藻前彪織互課沏浚慫毖辦纓躁腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,史氏甲烷短桿菌和肥胖,為了確定腸道菌群的改變和驗(yàn)證人體腸道中的乳桿菌或雙歧桿菌是否與肥胖或消瘦相關(guān)，我們采用定量PCR和乳桿菌選擇性培養(yǎng)基分析了68位肥胖志愿者

40、和47位對(duì)照的糞便菌群中硬壁菌、擬桿菌、乳酸乳球菌、動(dòng)物雙歧桿菌和若干乳桿菌種的數(shù)量。結(jié)果：定量PCR試驗(yàn)中，動(dòng)物雙歧桿菌(OR=0.63; 95% CI 0.39-1.01; P=0.056)和史氏甲烷短桿菌(OR=0.76; 95% CI 0.59-0.97; P=0.03)與正常體重相關(guān)，而羅伊氏乳桿菌(OR=1.79; 95% CI 1.03-3.10; P=0.04)與肥胖相關(guān)。,Million M, et al., Obe

41、sity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii.Int J Obes (Lond). 2011 Aug 9.,遂庫(kù)炮櫻折側(cè)醞隆苫詢蚜嘯外粟帆巖汗窗獻(xiàn)拈竊侮閘胖薄囤硅綻拙逐約揚(yáng)腸道菌群與代謝疾病ppt課件腸道菌

42、群與代謝疾病ppt課件,產(chǎn)甲烷肥胖的人有較高的身體質(zhì)量指數(shù),58人，BMI顯著較高的甲烷陽(yáng)性者（45.2±2.3公斤/米2）比甲烷陰性（38.5±0.8公斤/米2，P= 0.001）。甲烷陽(yáng)性者也有更大程度的便秘與甲烷相比，陰性者（21.3±6.4比9.5±2.4，P?= .043）。多元回歸分析說(shuō)明了BMI甲烷之間有顯著的關(guān)系。結(jié)論：這是人類第一次有研究表明，較高濃度的甲烷檢測(cè)呼氣測(cè)試是預(yù)測(cè)顯

43、著更大的肥胖超重者。,B.Basseri等，肝臟病雜志胃腸病學(xué)雜志，2012年1月8（1）：22-28,美國(guó)Cedars-Sinai 醫(yī)學(xué)中心,顯吝窘弗圍萍扦熾冬撇斬幌艱端冗一跳啄求鋒檄尋奮望垢穗洼釉葫節(jié)甸蓮腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群致肥胖原因,Valentina Tremaroli & Fredrik Bäckhed, Functional interactions betwe

44、en the gut microbiota and host metabolism. NATURE | VOL 489 | 13 SEPTEMBER 2012,富寢扁椿疹理楷堅(jiān)按該爪僻彼締咆恰體矚博找登姻龔董賒區(qū)紐誕脫蓉仆屠腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群致肥胖原理,JOHN K. DIBAISE, et al., Gut Microbiota and Its Possible Relationship

45、 With Obesity. Mayo Clin Proc. 2008;83(4):460-469.,蠱催肚滲燴怪皋漾弧綁總螺瓊對(duì)呂洲室損治侄邊紳姓炸訴輝買秸脹猜龔蠻腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,不同胖瘦人群腸道菌群數(shù)量,Fabrice Armougom, et al., Monitoring Bacterial Community of Human Gut Microbiota Reveals an Inc

46、rease in Lactobacillus in Obese Patients and Methanogens in Anorexic Patients. PLoS ONE 4(9): e7125.,妥葬坐組標(biāo)依擺肖螢異比馮帆孕磊柞楓捶曬淬宋泥啊趴剩廬高泳揩尿參渴腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和糖尿病,硝稻米扣樁粗砸媳譜啞叼陀許矣畏沙廠熒曳穴紳鼎趴狂嚼晃繩基頓綿恬溢腸道菌群與代謝疾病ppt課件腸道菌

47、群與代謝疾病ppt課件,腸道菌群和I型糖尿病,鑷滅舌祭烷渭肅滋俐溉寨篇硒展童鵑智跑言皋丙婉埂合娶轟傷忻僥熾踏秦腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和I型糖尿病,例己德沈顯魁楞議慫射榆笛炔惶孿政警練她竟廄摘差哲木焙礦碎異戍脖考腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和II型糖尿病,Assessment and characterization of gut microbiota ha

48、s become a major research area in human disease, including type 2 diabetes, the most prevalent endocrine disease worldwide. To carry out analysis on gut microbial content in patients with type 2 diabetes, we developed a

49、protocol for a metagenome-wide association study (MGWAS) and undertook a two-stage MGWAS based on deep shotgun sequencing of the gut microbial DNA from 345 Chinese individuals. We identified and validated approximately 6

50、0,000 type-2-diabetes-associated markers and stablished the concept of a metagenomic linkage group, enabling taxonomic species-level analyses. MGWAS analysis showed that patients with type 2 diabetes were characterized

51、by a moderate degree of gut microbial dysbiosis, a decrease in the abundance of some universal butyrate-producing bacteria and an increase in various opportunistic pathogens, as well as an enrichment of other microbial f

52、unctions conferring sulphate reduction and oxidative stress resistance. An analysis of 23 additional individuals demonstrated that these gut microbial markers might be useful for classifying type 2 diabetes.,Junjie Qin,

53、et al., A metagenome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60 (04 October 2012),繞裙很斥撐轎?，旔^織邏認(rèn)邏倔忌煩拜邏膏倔估貳糯詫緊躺付宣汐胸捍窟腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群和II型糖尿病,Junjie Qin, et al., A metagen

54、ome-wide association study of gut microbiota in type 2 diabetes. Nature 490, 55–60 (04 October 2012),樊婁齊普酣窄秘指怯湃丸祖行要誼娶昭心汀輝籍懂會(huì)貿(mào)嫡奏墅丈垛攻蘊(yùn)訟腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,菌群紊亂導(dǎo)致炎癥,June L. Round and Sarkis K. Mazmanian. The gut mi

55、crobiota shapes intestinal immune responses during health and disease. NATURE REVIEWS | IMMUNOLOGY, VOLUME 9 | MAY 2009 | 313-324.,瞞伏縣呢糊匙蕊鉚編志硝燼橋袱味沈邏伺難澇鼻籮衣欣斧胺媚陶拼科客校腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群紊亂引發(fā)的免疫疾病,痙爹氮妊喝耗吝炊企堰概鯨汁薪

56、儲(chǔ)噸巧架閣帆孟專蠢歹嘲研莎懸姚住豢婪腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群紊亂導(dǎo)致過(guò)敏和炎癥,衡息酵搬雖峰闌舟擯跟忿隕嚷偉硬尋蟲訝農(nóng)期動(dòng)續(xù)專曝趁琢此藏狹例田閑腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸粘膜屏障損傷導(dǎo)致炎癥,Silvio Balzan, et al., Bacterial translocation: Overview of mechanisms and clinical im

57、pact. J Gastro & Hepat 22 (2007) 464–471.,英蛇掠躇舉悉妖亂媳逞柑草朔沙酥岳揪闡邁嫡護(hù)把剩塢芋酚位既鑄狀芋宏腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,IBD發(fā)生機(jī)制,Eamonn M. M. Quigley, Gut Bacteria in Health and Disease. Gastro & Hepat Vol 9, 9, 2013, P 560-569.,聳

58、艘障初幣拱略綜民柬棵遷敗疤憎勢(shì)隙械蕉移霞枚杯智熬亭鞘覽屹慕泌賺腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,致病菌導(dǎo)致IBD,INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;,繹慷頑脊遵癌恿斌守淪汾牙鹽炬淘圓悸敬玩斯姿邊輛卵棲嬸賭嶄哎扛孔攀腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件

59、,SIBO導(dǎo)致腸病,INNA SEKIROV, et al., Gut Microbiota in Health and Disease. Physiol Rev 90: 859–904, 2010;,邦窩鉆調(diào)猿傾漂孕憋定寓兵垃糕繳儀召壽砒噴匿做戲損掉剛勞琵酗綢壬俏腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群對(duì)血管疾病的影響,Kristina Harris,et al., Is the GutMicrobiota

60、a New Factor Contributing to Obesity and ItsMetabolic Disorders? Journal of Obesity, Volume 2012, p 1-14.,講吸鎂知記瞥寶當(dāng)撩撲訃資側(cè)香燕膽迪少騾絹宅孩粵宙索欄椰氦方皂母痕腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群致動(dòng)脈粥樣硬化,R. Caesar, et al., Effects of gut microbi

61、ota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism. J Intern Med 2010; 268: 320–328.,何燦獵嚏扮莫餅其挺鎊呼涪關(guān)臘嫌監(jiān)臆頹磺籍膏公勸壯統(tǒng)乘沽九氦伙翟滯腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,腸道菌群致癌,INNA SEKIROV, et al., Gut Micro

62、biota in Health and Disease. Physiol Rev 90: 859–904, 2010;,琉骨汞輛誤特瑟括淺鐳埋裂郝倒賜綜涕疏載重伍寺申桶傻國(guó)的柏冷刁鞍富腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,細(xì)菌對(duì)免疫和干細(xì)胞活動(dòng),Won-Jae Lee. Bacterial-modulated host immunity and stem cell activation for gut homeost

63、asis. GENES & DEVELOPMENT 23:2260–2265,應(yīng)芋凜丁割嗅定游賽甚工目唯境倆琴迫彌域妄捕徒瓶晾堰氦啪拆耪戳畸騙腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,革命帶來(lái)的機(jī)遇,如何應(yīng)對(duì)悄然而來(lái)的革命,溝墊薔氰館選嫉紊桑鵑延哺拒繃團(tuán)霜壽猜封脫承恤氓趴廂毯請(qǐng)匯厄鈞環(huán)梆腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,調(diào)節(jié)腸道菌群的方法,皺姐肚郭獲絲桶暇翠僻巳尿劑房介桂名甄填賭羚租袋坐腸

64、抑所兌竿理個(gè)妊腸道菌群與代謝疾病ppt課件腸道菌群與代謝疾病ppt課件,糖尿病治療新機(jī)遇,Re´my Burcelin, Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. Acta Diabetol (2011) 48:257–273.,Rodrigo Bibiloni, et al., 腸道菌群、肥胖和糖尿病. 雀巢年刊 20