有機含氮小分子催化劑的設計、合成及在不對稱反應中的應用.pdf

1、委糾犬乎碩士學位論文(2005屆)有機含氮小分子催化劑的設計、合成及在不對稱反應中的應用Design，SynthesisandApplicationsofSmallNitrogencontainiligOrganocatalystsintheAsymmetricReactions研究生姓名棠萍指導教師姓名——專業(yè)名稱研究萬m沈宗旋(教授有機化學不對稱合成論文提交R期——2005年4月Design，SynthesisandApplicat

2、ionsofSmallNitrogen—containingOrganocatalystsintheAsymmetricReactionsAbstract1TheMichaeltypeadditionof4OXO2一phenylpent2enenitrileOfthecarbon—carbonbondformingreactions，theMichaelreactionhasbeenoneofthemoststudiedinsynthe

3、ticorganicchemistryIntheviewofrecentpapers，thesubstrates州mmultipleactivegroupshaven’tbeenreportedTheMichael—typeadditionof4一OXO一2一phenylpent一2enenitrile，whichWaSpreparedbyasimplemethod，wasstudiedintensivelyTheregioselect

4、ivityreactionyieldsandspeed，influencedbytemperature，solventsandcatalystswerediscussedCorrelativeproductswereidentifiedbyNMR2Design，synthesisandapplicationsofsmallnitrogencontainingorganocatalystsintheasymmetricreactionsE

5、nvironment—friendsmallnitrogen—containingorganocatalystsaledevelopedrapidlybecauseoftheirfacilerawmaterial，easysyntheticmethodsThissubjectincludesmainlythreeparts：(1)SynthesisofthreeorganocatalystsderivedfromLProlineandt

6、heirapplicationsindirectasymmetricAidolreactionandMichaeladditionreaction(2)ExplorationofUllmannreactioncatalyzedbyLPralineandCuI(3)OnepotandthreecomponentdirectMannichreactioncatalyzedby(2S，4S)4phenoxypyrrolidine一2carbo