磁共振彌散張量成像在腦星形細胞瘤中的診斷價值初探.pdf

1、山西醫(yī)科大學碩士學位論文磁共振彌散張量成像在腦星形細胞瘤中的診斷價值初探姓名：陳志剛申請學位級別：碩士專業(yè)：影像醫(yī)學與核醫(yī)學指導教師：張輝20080325“f明醫(yī)科人學碩L學位論文DiagnosisvalueofdiffusiontensormagneticresonanceimaginginthecerebraIastrocytomasAbstractPurposeToevaluateclinicalsignificanceofdif

2、fusiontensorimaging(DTI)inastrocytomasandtOreportcharacteristicDTIpatternsthatmaybehelpfulingradingastrocytomasMaterialsandMethods28patientsofastrocytomaswithpathologicconfirmationunderwentroutineMRjenhancedanddiffusiont

3、ensorimagingexaminationTheyaredividedintotwogroups：12patientsoflowgradeastrocytomas(LGA)，16patientsofhighgradeastrocytomas(HGA)，including7patientsofanaplasticastrocytoma(AA)and9patientsofglioblastomamultiforme(GBM)TheDTI

4、mapswerecalculatedaswellasmeasurementsofmeandiffusivity(MD)andFAvaluesoftheregionofinterestincludingtheenhancementnecrosis，edemaoutsideedemaandcerebralparenchymaofthenormalsideAcorrespondingtheMD、FAwereobtainedfrombotllt

5、heregionsofenhancement，necrosis，edemaandcorrespondingnormalbrainofeachgroupandthatofbetweentwogroupsFibertractographywasreconstructedthatdiaplaytheencounteredpatternsoftumorrelatedalterationtocerebralwhitemaaerResultsWeo

6、bserveddecreasedFAvalueofastrocytomawhichdisplayedashypointensesignalinFAimage，mostofthelesionsdisplayedisodensityorhyperintensesignal，IntheregionsofinteresttheMDFAvalueschangedsignificantlybycomparingwitllthatofnormalco

7、ntrolofbraintissueAsignificantdifferencealsoexistedwimtheMDvalueintheregionofenhancementbetweenthetwogroupsofastrocytoma(1061士0182，0882q：0088x103mm2／s，P005)Furthermore，FibertractographyandFAmapCallgaveaquickandintuitiveo

8、verviewofthedisplacedcourseofwhitemattertractsinthreedimensionalspaceConclusionThevaluesarehelpfultOdiagnosisthegradeofastrocytomas，whichistheMDvalueintheregionofenhancement，FAvalueintheregionsofedemaandoutsideedemacombi

9、ned、ⅣithconventionalM對，DTImayimprovediagnosticaccuracyofastrocytomaandprovidesahelpfultechniqueofquantitativeanalysisforgradingonMRimagesFibertraetographycandisplaythedetailedrelationshipbetweentumorsandnearbywhitematter