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1、一、投稿信1.DearDr.DefendiML:Iamsendingamanu.entitled“”by–whichIshouldliketosubmitfpossiblepublicationinthejournalof.Yourssincerely2.DearDr.A:Enclosedisamanu.entitled“”bysbwhichwearesubmittingfpublicationinthejournalof.Wehave
2、chosenthisjournalbecauseitdealswith.Webelievethatsthwouldbeofinteresttothejournal’sreaders.3.DearDr.A:Pleasefindenclosedfyourreviewaniginalresearcharticle“”bysb.Allauthshavereadapprovethisversionofthearticleduecarehasbee
3、ntakentoensuretheintegrityofthewk.Nopartofthispaperhaspublishedsubmittedelsewhere.NoconflictofinterestexitsinthesubmissionofthismanuwehaveattachedtothisletterthesignedlettergrantinguspermissiontouseFigure1fromanothersour
4、ce.Weappreciateyourconsiderationofourmanuwelookfwardtoreceivingcommentsfromthereviewers.二、詢問有無收到稿件DearEditsWedispatchedourmanu.toyourjournalon3August2006buthavenotasyetreceiveacknowledgementoftheirsafearrival.Wefearthatm
5、ayhavebeenlostshouldbegratefulifyouwouldletusknowwhethernotyouhavereceivedthem.Ifnotwewillsendourmanu.again.Thankyouinadvancefyourhelp.三、詢問論文審查回音DearEdits，Itismethan12weekssinceIsubmittedourmanu.(No:)fpossiblepublication
6、inyourjournal.Ihavenotyetreceivedareplyamwonderingwhetheryouhavereachedadecision.Ishouldappreciatedyourlettingmeknowwhatyouhavedecidedassoonaspossible.四、關于論文的總體審查意見1.Thisisacarefullydonestudythefindingsareofconsiderablei
7、nterest.Afewminrevisionarelistbelow.2.Thisisawellwrittenpapercontaininginterestingresultswhichmeritpublication.Fthebenefitofthereaderhoweveranumberofpointsneedclarifyingcertainstatementsrequirefurtherjustification.Therea
8、regivenbelow.3.AlthoughtheseobservationareinterestingtheyareratherlimiteddonotadvanceourknowledgeofthesubjectsufficientlytowarrantpublicationinPNAS.Wesuggestthat11.Ifeelthatthereviewer’scommentsconcerningFigures12resultf
9、romamisinterpretationofthedata.12.Wewouldhaveincludeanonproteininhibitinoursystemasacontrolifonehadbeenavailable.13.WeprefertoretaintheuseofTable4freasonsthatitshouldbeclearfromthenewparagraphedattheendoftheResultssectio
10、n.14.Althoughreviewerdoesnotconsideritisimptanttomeasurethetemperatureofthecellsweconsideritessential.15.Therunningtitlehasbeenchangedto“”.16.TheMaterialsMethodssectionnowincludesdetailsfmeasuringuptakeofisotopeassayingh
11、exokinase.17.TheconcentrationofHATmedia(page12paragraph2)wasincrectlystatedintheiginalmanu.Thishasbeenrectified.Theauthsaregratefultotherefereesfpointingouttheirerr.18.Assuggestedbybothrefereesadiscussionofthepossibility
12、oflaseractiononchromosomehasbeenincluded(page16paragraph2).19.Weincludedanewsetofphotographswithbetterdefinitionthanthoseiginallysubmittedtowhichascalehasbeenadded.20.FollowingthesuggestionoftherefereeswehaveredrawFigure
13、34.21.TwofurtherpaperspublishedsinceouriginalsubmissionhavebeenaddedtothetextReferencesection.Theseare:22.Weshouldliketothanktherefereesftheirhelpfulcommentshopethatwehavenowproducedamebalancebetteraccountofourwk.Wetrust
14、thattherevisedmanu.isacceptablefpublication.23.Igreatlyappreciatebothyourhelpthatoftherefereesconcerningimprovementtothispaper.Ihopethattherevisedmanu.isnowsuitablefpublication.24.Ishouldliketoexpressmyappreciationtoyout
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