PMBP席夫堿配體及配合物的合成、晶體結構研究、生物活性測定和量子化學計算.pdf

1、天津師范大學碩士學位論文PMBP席夫堿配體及配合物的合成、晶體結構研究、生物活性測定和量子化學計算姓名：楊云申請學位級別：碩士專業(yè)：物理化學指導教師：王瑾玲繆方明2002.4.1AbstractSinceSchiffbasecompoundsareeasytoprepareandhavehighbiologicalactivity，theresearchofSchiffbasesisstilloneofthecentralissuesi

2、nthecoordinationchemistrybiomedicineandpharamaceuticalchemistryfieldInaddition，recentresearchesmanifestedthatSchiffbasecompoundswillprobablybecomethenewtasksofmaterialchemistryInthisthesis，wereportthesynthesisof14kindsof

3、complexesofmetalnitratewithSchiffbasesderivedfrom1benyl一3一methyl4benzoyl—pyrazolin5一oneand(ochloro，m—chloro，P—chloro，24一dichloro)aniline，4aminoantipyrine，characterizedbyIRUvTGDTA，andelementalanalysisThetwocrystalstructur

4、eanalysisofSchiffbaseligandsderivedfromlbenyl3methyl4一benzoylpyrazolin一5oneandm—chloroaniline4aminoantipyrinebyXraydiffra一ctionmethodindicatesthattheyareneutraldentatesinenamineketoformButwhentheycoordinatedwithmetal，the

5、ywillloseoneprotonandbecometoonevalentnegativeligand，provedbythecrystalstructureofCo斗complexesderivedfromthe1benyl一3methyl，4benzoyl——pyrazolin5oneandmchloroanilineSchiffbasewhichdeterminedbyUSTheantibacterialactivityofSc

6、hiffbasecompoundsatdifferentconcentrationsagainstEColiandSauresaredeterminedTheresultsindicatematalmostallcompoundshavetheactivityofinhibitingthegrowthoftwobacteriaAlso，somecomplexesmayinhibittheformationofO2‘Usingquantu

7、mchemistrymethodperformsthecalculationsofthreecrystalstructuresWediscussthereactionmechanismofSchiffbaseformationTherelationshipbetweenstructureandactivityisalsodiscussed，offeringimportanttheorybasisforfutureresearchesKe