哮喘兒童吸入糖皮質(zhì)激素治療的回顧性研究.pdf_第1頁
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1、遵義醫(yī)學(xué)院碩士學(xué)位論文哮喘兒童吸入糖皮質(zhì)激素治療的回顧性研究姓名:湯正珍申請(qǐng)學(xué)位級(jí)別:碩士專業(yè):兒內(nèi)科指導(dǎo)教師:鄭躍杰20110524遵義醫(yī)學(xué)院碩士學(xué)位論文哮喘兒童ICS治療的回顧性研究RetrospectiveStudyofAsthmaticChildrenReceivedInhaledCorticosteroidTherapyAbstractObjective:Toassesstheprognosisofasthmaticchild

2、renreceivedinhaledcorticosteroid(ICS)therapyfor5years,andexploretherelevantfactorswiththechildhoodpersistentasthmaMethods:Theretrospectivestudywascarriedoutin186asthmaticchildrenreceivedtreatmentoflCSfiom20032004inShenzh

3、enChildren’ShospitalThepatientswereassessedbyquestionnaire,lungfunctionexaminmionandskinpricktests(SPDResults:186patientsfinishedtheinvestigationThetotalcontrolledratein145casesreceivedICStherapy(morethan3months)was476%,

4、whichwassignificantlyhigherthanthat(22%)ofthepatientswithoutICStherapy(notreceivedorlessthan3months)Therewasnosignificantdifference(PO05)insex,age,familyhistoryofallergies,andparentalhistoryofasthmabetweencontrolledandpa

5、rtly/uncontrolledgroupsHowevertheincidencerateofallergyincontrolledgroupWassignificantlyhigherthanthatofthosewithpartly/uncontrolledfPO05)inlungfunction(PEForFEV1)andFEF25/7565%abnormalityratebetweenthechildrenlreceivedI

6、CStherapyandthosewithoutICStherapy_TheinitialICStreatmentinvariedageandcoursesofasthmahasnoeffects011asthmacontrolrateInpartly/uncontrolledgroup,numberofpatientswithICStherapyformorethan2yearsandpersistentICStherapyWassi

7、gnificantlyhigher伊O05)Conclusions:ThelongtermcontrolinasthmaticchildrenisnotsatisfactoryOnly42%patientsachieveandmaintaintotalcontrolledafter5yearsICStherapyCansignificantlyimproveasthmacontrolchildrenwithpersistentasthm

8、a,theeffectsofICStreatmentmaynotberelatedtotheageofinitialtreatment,andcourseofdiseaseInordertoachieveandmaintainItotalcontrolofasthma,long—termandcontinuousICStherapyisnecessaryKeywords:Asthma;Children;Glucocorticoid;Tr

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