妊娠不同時(shí)期缺氧對(duì)成年子代大鼠心臟結(jié)構(gòu)及局部RAS的影響.pdf

1、福建醫(yī)科大學(xué)博士學(xué)位論文妊娠不同時(shí)期缺氧對(duì)成年子代大鼠心臟結(jié)構(gòu)及局部RAS的影響姓名：王凌星申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：內(nèi)科學(xué)（心血管?。┲笇?dǎo)教師：黃子揚(yáng)20100601■■，■■●■■■■，一■IneIntIuenceOtnVpoXIaaUnngaItterentPreanantstagesonthecardiacstructureandtissueRASinadultoffspringrats一[Abstract]ObjectiveTo

2、studytheinfluenceofhypoxiaduringdifferentpregnantstagesonthemyocardialremodelingandcardiacRASinadultmaleoffspringMethods24pregnantratswererandomlyassignedtofourgroupsasfollows：hypoxiagroupstartedinearlypregnancy(fromday3

3、today21ofpregnancy)，hypoxiagroupstartedinmid—pregnancy(fromday9today21ofpregnancy)，hypoxiagroupstartedinlatepregnancy(fromday15today21ofpregnancy)，andcontrolgroupEachgroupcontained6animalsTheleftventricularweightindex，th

4、ediameterofmyocardialfibre，themRNAandproteinexpressionofcollagenIandcollagenHI，theexpressionofACE—AngII—ATlaxisandACE2一Ang一(1—7)一Masaxisintheleftventricleofmaleoffspringratsat3monthsand5monthsofageweredetectedineachgroup

5、ResultsHypoxiastartedinearlyormiddlestageofpregnancyincreasedthemRNAandproteinexpressionofcollagenIandcollagenHIintheleftventricleofmaleoffspringrats，butwithouthypertrophicmyocardialcells，andthecardiaccollagendepositionw

6、asindependentofthechangesofbloodpressureHypoxiaduringpregnancycouldactivatethecardiacACE—AngII—ATlaxisinadultmaleoffspringbychangingthemRNAandproteinexpressionofATtreceptors，theproteinexpressionofACEorthegenerationofAngI