紫外光譜法在藥物多組分同時測定及相互作用分析中的應(yīng)用.pdf

1、分類號UDC密級學(xué)號彳房大季碩士學(xué)位論文論文題目：紫外光譜法在藥物多組分同時測定及相互作用分析中的應(yīng)用論文作者：劉崢蕞暴、登：％警蓉：夏之寧教授重慶大學(xué)申請學(xué)位級別：碩士專業(yè)名稱：分析化學(xué)論文提交日期：2002年4月20日答辯日期：2002年5月25日學(xué)位授予單位：重慶大學(xué)授位日期：年月日答辯委員會主席：劉紹璞教授論文評閱人：馮新瀘教授李勤耕副教授2002年4月20日英文摘要ABSTRACTThesimultaneousdetermin

2、ationofcomponentsinmulticomponentdrugsisalwaysencounteredinpharmaceuticalanalysisParacetamol，CaffeineandChlorphenaminemaleatearemaincompositionsofmedicineforthecoldT11ispapertellsthedeterminationofeachcompositioninthewri

3、tesystemconsistsofabovedrugsbychemomelricsandUVspectrophotometryUVspectrophotometrycombined謝血chemometricstodeterminatemulticomponentdrugsisveryvaluableforitsaccuracysimplicityandlowcostThechemometricsmethodsdealtwithinth

4、isarticlearemultiplelinearregression(MLR)，Kmetricmethod(K)andPmetricmethod(P)Comparingtheresultsofeachmethod，conclusionCanbemadeasfollowing：MLR，KandPa∞allsuitableinthissystem，howeverwhenmulti—affectexistindirectcalibrati

5、on(KP)isbetterthandirectcalibration(MLR)AndPjSthebestofallinthissystem，themeanrecoverypercentageandRSDofParacetamoi。CaffeineandChlorphenaminemaleateareasfollowing9612％，141％；9830％，130％；10142；108％Conditionsuchassolventandw

6、avelengtharealsodiscussed，bestconditionwasgetAspartsofinteractionresearchthisarticlealsouseUVSpectroscopytoinvestigatetheinclusionofB—cyclodextrin(p—CD)withparacetamolandtheinteractionofchlorphenaminemaleatewithbovineser

7、Tnalbumin(BSA)MethodofanalysisinteractionbyUVspectroscopyisfoundedwhenspectraoverlaysThereforbroadentheareaofUVspectroscopyininteractionresearchB—CDinteractwithparacetamolandforminclusioncompoundinwaternlcinclusionconsta

8、ntis4361021／m01TheheractionofChlorphenaminemaleatewithBSAbelongtoelectrostaticmodel，theyarecombinedbyelectrostaticattractionAccordingtothismodaltheconstantis132103I／mol，nemaxmolratioiS40TheconcentrationofChlorphenaminema