ANNEXIN Ⅱ、CD44v6和MMP-2在肺鱗癌、腺癌中的表達(dá)及其臨床意義.pdf

1、蘇州大學(xué)碩士學(xué)位論文ANNEXINⅡ、CD44v6和MMP2在肺鱗癌、腺癌中的表達(dá)及其臨床意義姓名：任軍申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：胸心外科指導(dǎo)教師：謝宗濤20090301ANNEXINII、CD44v6、MMP2在肺鱗癌、腺癌中的表達(dá)及其臨床意義英文摘要SignificanceofANNEXINII、CD44v6andMMP一2expressioninsquamouscellcarcinomaandadenocarcinomaofthel

2、ungAbstractObjective：TodetecttheexpressionofANNEXINII、CD44v6andMMP一2insquamouscarcinomaandadenocarcinomaofthelungandinvestigatetheirrelationships；analysetheirrelationshipsbetweentheirexpresssionsandclincoipathologicalpar

3、ametersMethods：ImmunohistochemistryEnVisionmethodwasadoptedtodeterminetheexpressionofANNEXINII、CD44v6andMMP2in70casesofsquamouscarcinomaandadenocarcinomaofthehumanlungand15casesnormalpulmonarytissuesResults：Thepositiveex

4、pressionratesofANNEXINII、CD44v6、MMP一2insquamouscarcinomaandadenocarcinomaofthelungWas5857％(41／70)、7571％(53／70)、7111％(50／70)respectivelyshowingasignificantlydifferencebetweennormalpulmonarytissuesandsquamouscarcinomaandad

5、enocarcinomaofthelung(P005)AndnocorrelationWasfoundbetweenANNEXINII、MMP2expressionandthesmoking、thedifferentiatedlevel、histologicaltype，butcloselyrelatedtoPTNMstageandlymphnodemetastasisinlungcancerpatients(P005)Theexpre

6、ssionofCD44v6Wasnotcorrelatedwiththesmokingandthedifferentiatedlevel，butcorrelatedwithP—TNMStage、histologicaltypeandlymphnodemetastasisinlungcancerpatients(P005)TheexpressionsofANNEXIN11waspositivelycorrelatedwithexpress

7、ionofCD44v6(r=0335，P005)；theexpressionsofANNEXIN11waspositivelycorrelated、析tllexpressionofMMP一2(r=0238，P005)；theexpressionsofCD44v6waspositivelycorrelatedwithexpressionofMMP一2(r=0306，P005)Conclusions：ANNEXINII，CD44v6andM