二甲雙胍治療多囊卵巢綜合征伴胰島素抵抗患者的療效觀察.pdf

1、青島大學(xué)碩士學(xué)位論文二甲雙胍治療多囊卵巢綜合征伴胰島素抵抗患者的療效觀察姓名：李曉林申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：婦科學(xué)指導(dǎo)教師：孫寶治20050514ClinicalobservationofmetforminintreatmentofpatientswithpolycysticovarysyndromeandinsulinresistaneeAbstractObjectiveTostudytheeffectsofmetforminontr

2、eatingpatientswitllpolycysficovarysyndrome(Pcos)andblsulinresistance(R)，Methods30patientswjmPCOSandIRwereselectedasstudygroupand30normalwomenascontrolgroupTheclinicalsymptoms，reproductivehormones，suwnmglucoseandinsulinle

3、velswereobservedAttheendof12weektherapywithmefformin，subjectswerereevaluatedandaboveparametersweremeasuredinstudygmupResultsTllestudygrouphadmarkedlyhigherlevelsinbodyiTIaSSindex(BMI)waist／hipratio(WHR)，F(xiàn)errimenGallweySC

4、Ore(FGscore)，luteinlzinghormone4H)，luteiulzinghormone／folliclestimulatinghormone(LH／FSH)，testosterone(T)，freetestosterone(FT)，androstenedione(A2)，dihydroepiandrosteronesulfate(DHEAS)，fastingbloodghicose(FBG)，tastinginsul

5、in(FINS)，insulinresistancehomamodel(Homa墩)，HomaBcall，areaundercurveglucose(AUC。)，@／caundercnrveinsulin(AUCOthanthecontrolgroup(P0001一O05)Thestudygrouphadmarkedlylowerlevelsinsexhormonebinding酉obulin(SHBG)，insulingrowthfa

6、ctorbindingprotein1(IGFBP一1)，insulinsensitivityindex(ISl)thanthecontrolgroup(PO，05)TheotherswerenotsignificantlydifferentbetweentwogroupsAfteradministrationofmefforminfor12weeksinthestudygroup，22of30(73％)casesrecoveredov

7、ulationand4of30(13％)casesobtainedpregnancyBMIW玎tFGscore，LH，LH／FSH，衛(wèi)FT，A2，DHEAS，F(xiàn)INS，HomaIR，HorrmBcell，AUCaAuClweredecreasedsignificantly(PO01—005)andSHBGIGFBP1，ISlwereincreasedsignificantlyaftertreatment(P0。05)。Nodiffere