常壓高氧環(huán)境對早產大鼠腦損傷的研究.pdf

1、青島大學碩士學位論文常壓高氧環(huán)境對早產大鼠腦損傷的研究姓名：趙秀俠申請學位級別：碩士專業(yè)：小兒內科指導教師：姜紅20080607Hyperoxia—inducedBrainInjuredinPrematureRatsAbstractobjecfiveToexplorethedynamiceffectofnormobafichyperoxia(NH)onsurvivalsituationandmorphologiccharacterist

2、icsinprematureratsMethodsOnehundredninety—twoimmaturerats，bornatagestationalageof21days，wererandomlyexposedtooxygen(30％02)，oxygen(60％02)，oxygen(95％02)，orroomairafterbirthBrainhistologicalstudyafterhematoxylineosinstainan

3、dthecontentsofMDAandtheenzymeactivityofSODandincerebraltissueweremeasuredonthe0d，3thd，5thd，10thdafteroxygenexposureinthreehyperxiagroupsandaircontrolsResultsComparedwithaircontrolsandhyperxiagrouplneuronaldegenerationand

4、edemawereseeninearlystage，andwereaggravatedat3daysafteroxygenexposureMDAincreasedwithages，whileMDAdecreasedat5daysthenregaintonormallevelAndSODdecreasedat0day，whichwereaggravatedsignificantlyat3daysandthenregainedtonorma

5、llevelat10daysComparedwithairgrodpandhyperxiagroupl，F(xiàn)=9391“78697，q=482～5350，(P001)Andcomparedwithairgroupandhyperxiagroupl，hyperxiagroup2at10days，MDAincreasedandSODdecreasedofhyperxiagroup3F=403“526，q=080～505，P005，001Con

6、clusionsUnremittingnormobafichyperoxiaexposurecanresultsinbraininjuryinimmatureratsAppropriateoxygenconcentrationandreasonableexposuretimecancontributetoreducetheprobabilityofbraininjured，alsocanrelievethedegreeofbrainin

7、jured，whichprovideevidencesforpreventhyperoxia—inducedbraininjuredinprematureinfantsPostgraduatestudent：Zhaoxiuxia(Pediatrics)DirectedbyProLJiangHongKeywords：immaturerats；hyperxia；braininjured；superoxidedismutase；maIondj