低劑量左旋多巴對帕金森病大鼠紋狀體乙酰膽堿及M1、M2受體的影響.pdf

1、華中科技大學(xué)碩士學(xué)位論文低劑量左旋多巴對帕金森病大鼠紋狀體乙酰膽堿及M1、M2受體的影響姓名：蔡敬杰申請學(xué)位級別：碩士專業(yè)：神經(jīng)病學(xué)指導(dǎo)教師：曹非副201005華中科技大學(xué)碩士學(xué)位論文華中科技大學(xué)碩士學(xué)位論文5EffectsofLowDosesofLevodopaAdministrationonStriatumAcetylcholineM1、M2ReceptsExpressioninParkinsonianRatsDepartmento

2、fNeurology，UnionHospital，TongJiMedicalCollege，HuazhongUniversityofScienceTechnologyPostgraduate:CaiJingjieTut:ViceProfessCaoFeiAbstract【Objective】Toinvestigatetheeffectsoflowdosesoflevodopaadministrationonstriatumacetylc

3、holineMl、M2receptsacetylcholinecontentexpressioninParkinsonianrats.【Methods】6OHDAwasstereotaxieallyinjectedintoratstomakeratsmodelofPDRatswereromlydividedinto5groupstheblankgroupThemodelgroupthedrug7d14d21dgroupImmunohis

4、tochemistrywasmeasuredbyMlM2receptsinthestriatumexpression.HPLCECDwasusedtomeasurethecontentofAchinthestriatumatdifferentsurvivaltimes7d14d21d.【Results】MlreceptsintheexpressionofaratmodelofParkinsonsdiseasetheaverageopti

5、caldensityishigherthanthenmalcontrolgroupafter14dtheaverageopticaldensityofMlreceptproteindecreasedsignificantlycomparedwithmodelgroup(P0.05)themedication21dMlreceptexpressioninpostrecoveryM2receptproteinaverageopticalde

6、nsityinParkinsonsdiseasemodelgroupthaninthecontrolgroupdecreasedsignificantly(P0.05)butthedrughadnosignificantpickupaftertheintervention(P0.05).ThelevelofAchdecreasessignificantlyinthePDrats7dinterventionwithlevodopathec