參麥注射液對腦出血大鼠HSP70表達的影響和神經細胞保護作用機制的實驗研究.pdf

1、分類號：R74334密級：湖南中醫(yī)學院V7766G7編號：碩士學位論文論文題目：墨蠹垂盤盜塾墮窶壘蠢遺HSPT0塞達的型響壟進經細筵堡莖絲翅盔!型塑塞鑒受塞學科專鼗：主魚笙全監(jiān)盎疊簍塑登研托生姓名：童：三塞導師姓名及職稱：一煎澤重～塑撞一TheexperimentalStudyOfTheEffectofShenmaiInjectononTheExpressionofHeatShockProteins70(HSP70)AndThemech

2、anismofProtectiveEffectsonTheNeuronInTheRatBrainAfterIntracerebralHemorrhage(ICH)ABSTRACTWithSprapue—DewleyRatsmodelswithintracerebralhemorrhage(ICH)，ThisreseachinvestgatedtheeffectsofShenmai(SM)Injectiononthepathologics

3、ignofthenervesystem，andthepathologicchangesofthebraintissuesstructureintheareasofischemicpenumbral(IP)aroundhematomaandthehippocampalgyrusofoperatedsides，WealsoobservedtheeffectsofSMInjectionontheexpressionoftheheatshock

4、proteins70(HSP70)intheareasofhematoma、lIP、hippocampalgyrusandcotexofoperatedsidesResults：1Theeffectsonthepathologicsignofthenervesystem、thepathologicchangesofbraintissuesstructureintheareasofischemicpenumbral(IP)aroundhe

5、matomaandthehippocampaigyrusofoperatedsidesintheratsmodelswithICH，theratmodelsweremadebyinjectingCollagenasetypeVIIstereotaxicallyobeservtionwasscheduledintotburpoint(1day3day5day7dayafteroperation)，whichwasstudiedbyHEst

6、ainingandHSP70immunohistochemistryWefoudthatinthegroupsofSMInjectiontreatment，thepathologicsignsofthenervesystemwerealleviated，hematomawereabsorbedwell，thepathologicchangesofthebraintissuesstructureintheareasofIParoundhe

7、matomaandhippocampalgymsofoperatedsideswerereduced，thestructureofneuronswererelativelyimegratedTheresultssuggestedthatSMInjectionprovidedaprotectiveeffectontheneuronbyacceleratingthehematomaabsorptionandantagonizingthehy