磁共振灌注成像評價(jià)血管內(nèi)皮抑制素聯(lián)合介入治療胃腸道來源肝轉(zhuǎn)移癌的療效.pdf

1、徐州醫(yī)學(xué)院碩士學(xué)位論文磁共振灌注成像評價(jià)血管內(nèi)皮抑制素聯(lián)合介入治療胃腸道來源肝轉(zhuǎn)移癌的療效姓名：吳垠垠申請學(xué)位級別：碩士專業(yè)：影像醫(yī)學(xué)與核醫(yī)學(xué)指導(dǎo)教師：許健201203——徐州醫(yī)學(xué)院碩士學(xué)位論文—————————————————————————二—————L二二二二_=—一一EvaluationofEndostarcombinedwithinterventionaltherapyfortreatmentofgastrointestina

2、ltumorshepaticmetastasisbyDynamicMRImagingAbstractObjectiveGastrointestinaltumorsisacommonmalignanttumorwithsignificantmorbidityinChinaBecauseofthelowrateofearlydiagnosis，mostpatientswithnepaticmetastasishadpoorprognosis

3、Interventionaltherapybecamethetreatmentoffirstcnoiceinunresectablecases，andanti—angiogenesistherapytobeanewwavoftumortherapyTheaimofourstudywastoexplorethevalueofEndostarcombinedwithinterventionaltherapyingastrointestina

4、ltumorshepaticmetastasisbyDⅦ鋤icMRImagingMethodsAtotalof22histologicallyprovengastrointestinalcancerpatients，whohadfoundhepaticmetastasesafterradicalresectionofprimarytumorweretreatedwithEndostarcombinedinterventionalther

5、apyPatientsreceivedacombinationof1n昀VenousEndostar(15mg)ondays15，andintraarterialEpirubicin(2030rag)Tegafur(109)andOxaliplatin(85mg／m2)onday6ineverymouthAftert11reecvclesofcombinedtreatment，evaluatedclinicalcurativeeffec

6、tbythechangeofrumormorphologyandtumormarkersinpatients，observedtoxicityandqualityoflifeinpatientsduringclinicalfollow—upResultsAllpatientsfinishedthreecyclesofchemotherapyTheoverallresponseratewas5909％03cases)，inwhich3ca

7、sesofpatients(1364％)hadclinicalcompleteresponseAreasofnecrosisandcavitationmayoccurwithinmetumorToxicitvwasmoderate，andtherewerenochemotherapyrelateddeathsKPSscoresinpatientsweresignificantlyimprovedTheDCEMRIcharacterist

8、icsdramaticdeclineandtheIossesofKtrans，VeandiAUCweresignificancesinstatisticsConclusionPreliminaryresultsprovedtheEndostarcombinedinterventionaltherapywasasafeandpromisingregimenfortreatmentofgastrointestinaltumorshepati