2446.新型c2軸手性和手性吡咯烷酰胺催化劑的設(shè)計(jì)合成及不對(duì)稱催化反應(yīng)中的應(yīng)用

1、學(xué)校代碼：10663學(xué)號(hào)：4201410000391貴州師范大學(xué)碩士學(xué)位論文新型C2軸手性和手性吡咯烷酰胺催化劑的設(shè)計(jì)合成及不對(duì)稱催化反應(yīng)中的應(yīng)用NovelC2axisChiralChiralPyrroleAeCatalystswereDesignedSynthesizedofApplicationsinAsymmetricCatalyticReactions專業(yè)名稱：分析化學(xué)專業(yè)代碼：070302研究方向：有機(jī)合成申請(qǐng)人姓名：黃克俊導(dǎo)

2、師姓名：陳治明（教授）二〇一七年五月二十日ⅡAbstractganocatalysishasbecomeoneofthemostactiveattractivebranchinasymmetriccatalysissincethebeginningofthiscentury.Particylarythenearlylasttenyearshaswitnessdanenousgrowthconcerningnewcatalystdesig

3、nnewrectiondevelopmentnovelcatalyticconcepts.InthiscontextasymmetricenaminecatalysisHbondingcatalysisaretwoofimptantganocatalyticstrategiesthathaneasubstantialimpactonthisarea.Inspiredbythesefundermentalcatalyticstategie

4、swedesignedavaitetyofmultifunctionalchiralganocatalysts.TherefethehighercatalyticactivityofchiralpyrrolidineaeC2axialchiralBINOLaeganocatalystsweredesignedsynthesizedfmcommerciallyavailableLprolinewereusedintwodifferenta

5、symmetriccatalyticreactionhaveachievedgoodresults.1.TheasymmetricMichaeladditionreactionofanthronetoβnitrostyrenewascatalyzedbynovelfourkindsofC2axischiralBINOLaecatalysts.Theoptimumconditionsfthisreactionarethemolarrati

6、oofanthronetonitroolefinis0.05mmol:0.05mmolusing15mmol%ofaC2axischiralganicsmallmoleculecatalystatroomtemperaturewiththepresenceof2mmoloftolueneasthesolvent.Therearetwelveenantiomericallyrichedsubstituentnitroanthronewit

7、honechiralcenterswassynthesizedallcompoundswereacterizedby1HNMR13CNMRIRmeltingpoint.2.Theasymmetricreactionofindoletoβnitrostyrenewascatalyzedbynovelfivekindsofchiralpyrroleaeganicsmallmoleculecatalyst.Theoptimumconditio

8、nsfthisreactionarethemolarratioofindoletonitroolefinis0.05mmol:0.05mmolusing10mmol%ofapyrrolidineaebasedganicsmallmoleculecatalystatroomtemperaturewiththepresenceof2mLofdichlomethaneasasolvent.Therearetwelveenantiomerica